This research deals with an approach to the Quranic presentation of the foundations of knowledge, Quranic verses has included set of guidelines and signals about the nature of knowledge and its foundations. Quran has presented these foundations in a unique method that combines between sense and reason in many verses, on the other hand between them and human experience which has confirmed through repeated and frequent transfer from generation to generation. Quranic method linked between epistemology and manifestation of the universe, and presented the foundations of knowledge in the context that highlights God's grace and mercy.