This study contains the five Objectives of Shariah and scientific applications mentioned in Surah al-Baqarah and verses from other Surahs so as to support and explain the Objective, on the belief that Islamic legislation combines rational and textual evidence in a unique civilized template. Tafsir scholars of the past have discussed in their commentary of the Book of Allah the issue of Objectives during their time. This study aims to present the models and methodologies of past commentators in discussing reality and to benefit from the great legacy that they have left; then collecting contemporary scientific applications that contribute to the realization of the Objectives, each objective individually discussed; and presenting Quranic texts that discuss Objectives aspects with scientific significance in the verses of Surah al-Baqarah specifically and other Surahs that discuss the same idea. The research problem is summarized in presenting contemporary scientific applications that contribute to the understanding of the five Objectives and the approach to address the raised issue, seeing that today’s reality is in dire need to broaden and deepen understanding on the Objective, especially the occurrence of many uncertainties and problems that require the best response and righteous argument guided by the light of Shariah. This study employed the inductive, descriptive, and deductive approaches. Among the most important results of this study is confirming that the Shariah does not contradict science and life, and that it is possible to deduce the Objectives of Shariah, which the legislation came to protect, by understanding the verses. Among the research results, as well, is cautioning against excessively examining scientific applications and bending the Quranic texts to suit the ideas. Rather, the Quranic texts are the foundation, then reality matches them. In addition, textual and rational evidence has built a scientific civilization and stood as bulwark against those who attempt to question Islamic legislation and stir up uncertainties and issues. Allah grants success.