The development of science and technology has significantly impacted people's daily lives. Humans depend on convenience and innovation, such as online transactions, presenting electronic documents as evidence in court, online education applications, and others. In Shariah principles, Maqāṣid Al-Sharīʿa plays an important role in taking care of the five main elements: the preservation of faith or religion (Hifz al-Din), the preservation of life (Hifz al-Nafs), the preservation of intellect (Hifz al-‘Aql), the preservation of lineage (Hifz al-Nasl), and the preservation of property (Hifz al-Mal). According to the religious perspective, any modern technology or innovation contradicting the five main principles is not permissible. However, to what extent are the five main principles applied to producing this development? This article explores the requirements for adopting science and technology to enhance human well-being, examines how Shariah's five main objectives can be integrated into the production of science and technology, and analyses the challenges in applying these objectives within this context. This article uses a qualitative approach via document analysis, utilising several sources such as classical Islamic and contemporary books, theses, journal articles, proceedings, websites, and working papers. The collected data is presented in the form of subthemes. The findings show that applying the five Shariah principles is crucial in producing innovation and modern technology for human well-being. This is because an innovation that violates the principle of Maqāṣid Al-Sharīʿa is automatically not accepted by Shariah, such as gender reassignment, semen banks, etc. This study summarises that the emerging manufacturing of technologies and innovations must align with the five principles of Shariah. The main objective is to produce good (jalbu al-maslahah) and reject all evil (dar'u al-mafsadah).