It is necessary for visually impaired users (VIUs) to be able to make use of information communication technologies (ICTs), especially e-Learning websites to acquire knowledge through them. This paper explores the factors that influence effective Islamic knowledge transfer (EiKT) via e-Learning websites for VIUs in Malaysia according to the knowledge providers (KPs), service providers (SPs) and VIUs. The paper is exploratory and applies thematic analysis to analyze the qualitative data that were collected through the use of 41 interviews with the three groups of participants. Four factors were identified which influence Islamic knowledge transfer (KT) through the use of this websites. The paper has identified the factors and suggests the considerations of these factors in making decisions on the transfer of Islamic knowledge to VIUs through the use of them.