Depression, anxiety and stress is a global major risk factor to worker’s health which leads to unmotivated and less productive worker. The objective of this study is to examine the prevalence of depression, anxiety and stress level at one of the Fire and Rescue Department in Negeri Sembilan. The research also explores the associated factor to depression, anxiety and stress and its coping strategy. Forty-two (42) firefighters was involved as the research subject. Six (6) firefighters have been selected for interview session. Qualitative and quantitative data was collected in this study. The prevalence of depression, anxiety and stress level has been measured using Depression, Anxiety and Stress Scale (DASS21). The result shows that the mean value for stress is 9.67, depression is 7.76 and anxiety is 8.11. The findings also shows that 18.4% (10 of the respondent) suffer from high level of depression, 31% (13 of the respondent) suffer from high anxiety while, 19% (8 of the respondent) had higher level of stress. This indicates that the firefighter involve in this study suffers depression, anxiety and stress. The data gained from interview sample reveals that amongst the contributing factor for stress, anxiety and depression are workload, negative community feedback and inconsistent order from the superiors. The respondents cope with stress through personal coping, spending time with family and friends, sharing with others and deploys Islamic approach. The findings from this study is useful for Fire and Rescue Department’s higher management, Government and other stakeholders to implement a policy and guideline to eliminate, manage and provide support to firefighter facing psychological issues. Keywords: Depression, Anxiety, Stress, Firefighter, Health