Browsing by Author "Boo N.Y."
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Publication Genotyping of OATP2 variants in a group of malaysian neonates using high-resolution melting analysis(Mary Ann Liebert Inc., 2012) ;Wong F.L. ;Boo N.Y. ;Othman A. ;Faculty of Medicine and Health Sciences ;Universiti Kebangsaan Malaysia (UKM) Medical Centre ;Universiti Tunku Abdul Rahman (UTAR)Universiti Sains Islam Malaysia (USIM)[No abstract available] - Some of the metrics are blocked by yourconsent settings
Publication Risk factors associated with unconjugated neonatal hyperbilirubinemia in Malaysian Neonates(2013) ;Wong F. ;Boo N.Y. ;Othman A. ;Faculty of Medicine and Health Sciences ;Universiti Kebangsaan Malaysia (UKM) Medical Centre ;Universiti Sains Islam Malaysia (USIM)Universiti of Tunku Abdul Rahman (UTAR)Objective: To investigate the risk factors associated with neonatal hyperbilirubinemia in Malaysian neonates. Methods: A prospective study was conducted to investigate the effects of glucose-6-phosphate dehydrogenase (G6PD) mutation, variant uridine diphosphate glucuronosyltransferase UGT1A1 gene and hepatic organic anion transporter protein (OATP2) gene on a group of neonates. Hyperbilirubinemia was defined as a total serum bilirubin level of >250 ?mol/l. Results: Of 318 neonates, 52 (16.4%) had hyperbilirubinemia. The incidence of G6PD mutation was 5.4% (15/280) among these infants. The incidence of G6PD mutation was significantly higher in the male neonates with hyperbilirubinemia (7.8%) when compared with the normal male neonates without hyperbilirubinemia (1.8%; p=0.03). Logistic regression analysis showed that the significant risk factors for neonatal hyperbilirubinemia were Malay ethnicity [adjusted odds ratio (OR), 2.77; 95% confidence interval (CI): 1.31-5.86; p=0.007] and G6PD mutation (adjusted OR, 3.29; 95% CI: 1.06-10.1820; p=0.039). The gender, birth weight and gestation age of neonates, variant c.211G>A and variant of OATP2 gene were not significant. Conclusions: Neonates with Malay ethnicity and G6PD mutation were at risk for hyperbilirubinemia. � The Author [2013]. Published by Oxford University Press. All rights reserved.