INTRODUCTION: The first step in the forensic identification is sex determination followed by age and stature estimation, as both are sex-dependent. The mandible is the largest, strongest and most durable bone in the face. Mandible is important for sex confirmation in absence of a complete pelvis and skull. AIM: The aim of the present study was to determine sex of human mandible from morphology, morphometric measurements as well as discriminant function analysis from the CT scan. MATERIALS AND METHODS: The present retrospective study comprised 79 subjects (48 males, 31 females), with age group between 18 and 74 years, and were obtained from the post mortem computed tomography data in the Hospital Kuala Lumpur. The parameters were divided into three morphologic and nine morphometric parameters, which were measured by using Osirix MD Software 3D Volume Rendering. RESULTS: The Chi-square test showed that men were significantly association with square-shaped chin (92%), prominent muscle marking (85%) and everted gonial glare, whereas women had pointed chin (84%), less prominent muscle marking (90%) and inverted gonial glare (80%). All parameter measurements showed significantly greater values in males than in females by independent t-test (p< 0.01). By discriminant analysis, the classification accuracy was 78.5%, the sensitivity was 79.2% and the specificity was 77.4%. The discriminant function equation was formulated based on bigonial breath and condylar height, which were the best predictors. CONCLUSION: In conclusion, the mandible could be distinguished according to the sex. The results of the study can be used for identification of damaged and/or unknown mandible in the Malaysian population.

Postoperative Cognitive Dysfunction (POCD) refers to the condition of neurocognitive decline following surgery in a cognitive and sensory manner. There are several risk factors, which may be life-threatening for this condition. Neuropsychological assessment of this condition is very im-portant. In the present review, we discuss the association of apolipoprotein epsilon 4 (APOE ?4) and few miRNAs with POCD, and highlight the clinical importance for prognosis, diagnosis and treatment of POCD. Microarray is a genome analysis that can be used to determine DNA abnormalities. This current technique is rapid, efficient and high-throughout. Microarray techniques are widely used to di-agnose diseases, particularly in genetic disorder, chromosomal abnormalities, mutations, infectious diseases and disease-relevant biomarkers. MicroRNAs (miRNAs) are a class of non-coding RNAs that are widely found distributed in eukaryotes. Few miRNAs influence the nervous system development, and nerve damage repair. Microarray approach can be utilized to understand the miRNAs involved and their pathways in POCD development, unleashing their potential to be considered as a diagnostic marker for POCD. This paper summarizes and identifies the studies that use microarray based approaches for POCD analysis. Since the application of microarray in POCD is expanding, there is a need to review the current knowledge of this approach. 2020 Bentham Science Publishers.

There are several confinement practices among the Malay community. It was noted that some of them can be scientifically proven beneficial to the body while some of them have unclear purposes of action and can be potentially harm. Thus, this study is aimed to identify the confinement practices and their associated factors among Malay mothers during the postpartum period. A cross-sectional study (n = 306) was conducted among Malay mothers and the respondents recruited through a validated self-administered questionnaire. The participants were recruited through convenience sampling. The survey was conducted online, in which the advertisement was disseminated through social media and online messenger (WhatsApp). Overall, majority of the Malay mothers adhered to confinement practices (100%). Mothers who undergo spontaneous vaginal delivery (SVD) were associated with doing postpartum massage (AOR 5.31, 95%CI 2.72-10.39), consuming traditional herbs (AOR 2.022, 95%CI 1.11-3.70), and showering every day (AOR 3.46, 95%CI 1.08-11.07). Meanwhile, mothers with better household incomes tend to have meals prepared for confinement (AOR 1.99, 95%CI 1.19-3.32) and postpartum massage (AOR 2.75, 95%CI 1.18-6.41). Malay mothers with SVD and better income tend to adhere to confinement practices. However, the results of this study are not generalized to other ethnicities in Malaysia (Chinese, Indian, and others).

The workers and employees in various institutions are subjected to different shifts and work schedules. The employees work not only at daytime but also during odd hours at night. The biological clock of an individual is often altered during night shifts. This affects the psychosocial well-being and circadian nutritional intake of the worker. Disturbance in circadian rhythm results in the development of metabolic disorders such as hypertension, dyslipidemia, dysglycemia, and abdominal obesity. In the present review, we discuss the nature of shift work, sleep/wake cycle of an individual, chrononutrition, dietary habits, and meal changes with regard to timing and frequency, related to shift work. We also discuss the relationship between nutritional intake and psychosocial well-being among shift workers. The review may be beneficial for prevention of metabolic disorders and maintaining sound psychological condition in shift workers. � 2020 by the authors. Licensee MDPI, Basel, Switzerland.

In this article, two co-authors were missing in the author list. The correct author list of this article is as follows. � 2019 Anatomy & Cell Biology.

Objectives: To establish the benefits of immature reticulocyte fraction (IRF) measurement using an automated hematology cells analyzer over absolute neutrophil count (ANC) in predicting bone marrow recovery post induction chemotherapy. Methods: A prospective observational study was carried out in the Departments of Pathology, Medicine, and Pediatrics, Universiti Kebangsaan Malaysia, Medical Center (UKMMC), Kuala Lumpur, Malaysia during a period of 19 months from April 2009 to December 2010 to assess the bone marrow recovery in patients with acute leukemia. A total of 22 patients in remission induction phases were enrolled in this study. The blood specimens were collected from day zero after chemotherapy, and every 3 days until patients recovered hematologically. All blood samples were measured for ANC and IRF using an automated hematology analyzer (Beckman-Coulter LH750). Results: The percentage of patients showing IRF recovery earlier than ANC recovery was 63.6% (14 out of 22 patients). There was a significant difference in the mean number of days for IRF recovery as compared with ANC recovery (14.05 and 17.18 days), p=0.005. Conclusion: This study proved that IRF was more useful in predicting bone marrow recovery in a patient with acute leukemia post induction chemotherapy compared with ANC. The IRF is not affected by infection, is easily measured, and inexpensive; thus, it is a reliable parameter to evaluate bone marrow reconstitution.

[No abstract available]

Introduction: The mental foramen is present on either side of the body of the mandible bone. This foramen transmits mental vessels and nerves. In forensic anthropology, mental foramen may be important for differentiating sex, estimating age and identifying various races based on morphology. The main aim of the present study was to determine the position, shape and diameter of the mental foramen according to sex, age and race by postmortem computed tomography in the Malaysian population. Materials and Methods: A total of 79 dentulous patients (48 males, 31 females) from 3 age groups (18-30 years, 31- 50 years, 51-74 years) were selected for this study, and ten parameters were observed for each mandible. The parameters were divided into two morphological and eight morphometric parameters. The morphometric parameters were measured by using Osirix MD Software 3D Volume Rendering. Results: Results showed that mandibular body length and height were significantly greater in males than in females by independent t-test. (p < 0.05). However, the mandibular body height was found to decrease significantly with age in both sexes by one-way Anova. It was observed that the shape of mental foramen was 45.6% oval and 54.4% rounded. About 44.3% of them were in line with the longitudinal axis of the second premolar tooth. Conclusion: It was concluded that mental foramen may be used for identification purposes, particularly for sex, age and race determination.

Objective: A clear knowledge of the location of supraorbital foramen (SOF) is vital for the surgeons, particularly in endoscopic surgery and regional block in crania. The aim of this study was to analyze SOF and notch in skulls of various ancestries. Methods: The anatomical variations of SOF and notch were examined in 100 adults skulls (55 males and 45 females) of the Malay, Chinese, and Indian ancestries by traditional measurement made with the Osirix software. The parameters included distance between supraorbital structure and nasal midline, shape, and transverse diameter of the SOF. Results: It was manifested that bilateral supraorbital notch (SON) was the most prevalent combination in both sexes and ancestries (61%), while combined SON and foramen (11%) were the least prevalent characteristic. The mean distances of supraorbital structure from nasal midline bilaterally in males were slightly greater than females. The horizontal diameter of SOF, notch and their distances from the nasal midline showed no difference between ancestries. Conclusion: This study would serve as a guide for the surgeons when surgery is performed on the scalp. It can help in the precise determination of reference points for supraorbital nerve blockade for the Malaysians. In addition, the variations exhibited in supraorbital measurements inevitably revealed that sex and ancestry should be taken into consideration when choosing samples for anatomical classification of crania. � 2018, Innovare Academics Sciences Pvt. Ltd. All rights reserved.

Objective: Determination of sex is one of the most important parameters for conducting biological profile of unknown skeletal remains in anatomical anthropology and forensic medicine. Mastoid bone is useful for the identification of sex, as it is the most protected bone and is resistant to damage, due to its anatomical position at the base of the skull. The aim of this study was to develop new equation for the estimation of sex from mastoid triangle in the Malaysian population. Methods: About 10 parameters were studied on 388 computed tomography scans of crania in 231 males and 157 females. The parameters comprised three sides of mastoid triangle, its perimeter and area on both sides. T-test was used to compare between the right and left sides and between males and females. Stepwise discriminant function was used to reveal the best discriminatory parameter and its classification accuracy. Results: Comparison of means by T-test revealed no difference between the right and left sides in both sexes. T-test showed a significant difference between males and females for all parameters. Perimeter of mastoid triangle was found to be the best parameter by stepwise discriminant analysis. The equation based on perimeter of mastoid triangle was developed with 84.4% classification accuracy. Conclusion: The developed equation could be used to assess sexual dimorphism of fragmented Malaysian crania with intact mastoid region. The achieved cross-validated classification was relatively high compared to that in other previous studies.

Mothers with infants in the Neonatal Intensive Care Unit (NICU) are at a higher risk of postpartum depression (PPD). Risk factors of PPD include environmental factors, psychological factors and biological factors. In this review, the aim was to identify the prevalence of PPD and its associated risk factors among mothers with infants in NICU. The relationship between dietary intake in relation to traditional postpartum practices with PPD is also discussed. Findings showed that PPD among mothers with infants in NICU was prevalent, ranging between 12.1% and 68%. Factors such as preterm birth, long hospitalisation and maternal role alteration were the most associated risk factors contributing to PPD. Consumption of food based on traditional practices was found to influence maternal mental health. Therefore, a rational approach in addressing mental health issues and adhering traditional food practices is needed in order to promote a postpartum mother's safe and healthy well-being. � 2020 Neonatal Nurses Association

Background. Anaemia is a global health problem including Malaysia. In adults, anaemia may affect work productivity. Iron deficiency anaemia and thalassaemia are common causes of anaemia in Malaysia. However, there is scarcity of data on national prevalence of iron deficiency anaemia and thalassaemia, especially in young adults. This cross sectional study was performed to determine the prevalence of iron deficiency anaemia and thalassaemia among medical students of Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Materials and Methods. Blood samples collected in EDTA tubes were analyzed for haemoglobin level and red cell parameters such as MCV, MCH and red cell counts. Samples with abnormal red cell indices were sent for analysis of RBC morphology, iron status, haemoglobin analysis and DNA analysis. Results. A total of 400 samples were available for this study. Fiftyeight (14.5%) students had hypochromic microcytic red cell indices in which 44 (11%) showed thalassaemia red cell indices while 14 (3.5%) had iron deficiency red cell indices which were finally confirmed by serum iron/TIBC analysis. Amongst those suspected to have thalassaemia, 12 (27.3%) were confirmed as alpha thalassaemia trait (??/--SEA), 11 (25%) as Haemoglobin-E trait, 8 (18.2%) as beta thalassaemia trait and 2 (4.5%) as Haemoglobin Constant Spring (??/?CS?). However, eleven students (25%) with thalassaemia red cell indices could not be confirmed with the common thalassaemia primers available, thus causes have yet to be established. Conclusion. Our prevalence of thalassaemia was high and thus we opine that better screening methods should be adopted. � Societ� Editrice Universo (SEU).

Sex determination is one of the main steps in the identification of human skeletal remains. It constitutes an initial step in personal identification from the skeletal remains. The aim of the present study was to provide the population-specific sex discriminating osteometric standards to aid human identification. The present study was conducted on 87 (174 sides) slices of crania using postmortem computed tomography in 45 males and 42 females, aged between 18 and 75 years. About 22 parameters of crania were measured using Osirix software 3-D Volume Rendering. Results showed that all parameters were significantly higher in males than in females except for orbital height of the left eye by independent t test (P < 0.01). By discriminant analysis, the classification accuracy was 85.1%, and by regression, the classification accuracy ranged from 78.2% to 86.2%. In conclusion, cranium can be used to distinguish between males and females in the Malaysian population. The results of the present study can be used as a forensic tool for identification of unknown crania. � 2017. Anatomy and Cell Biologylary.