The implementation of religiosity and psycho-spiritual health through the module instrumentation is deemed significant to the inmates. Both entities are found to be effective in producing positive result. It is also believed to be able to train and treat patients' mental state and behavioral state, thus from recurring bad behaviors. Several methods have been applied including: Cross survey, interview and questionnaire survey, which involves 40 inmates in the prison for various delinquencies. This research is going to analyze the effectiveness of the psychospiritual module on the prison inmates before and after treatment. Due to the respondents' location, this research conducted at the Kajang Women prison in Malaysia. This article also evaluates the influence of religiousness inculcated in the treatment of inmates, which promotes changes in positive attitude, daily lifestyle, mental health and self-management. The result illustrates positive outcome from the implemented module before and after the psychospiritual treatment. As conclusion, the study findings give strong support for the effectiveness of religious approach in improving spiritual health for women inmates in prison. Thus, religious approach is recommended as an alternative to the current allopathic treatment method in dealing with the problem especially for women inmates in prison.