Pyogenic granuloma (PG) is a benign hyperplastic, vascular proliferation either on the skin or mucosal membranes. It commonly occurs following traumatic or hormonal changes, particularly in pregnancy. While the lesions occur frequently in the oral cavity in the head and neck region, occurrence in the nasal septum is rarely reported. We report a case of a 23-year-old male with unilateral pyogenic granuloma of the anterior nasal septum, who presented with epistaxis and nasal blockage. Although intra nasal PG is rare, we advocate that PG be considered in any anterior nasal septum mass with epistaxis.