Browsing by Author "Hamid, NA"
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Publication The application of serum biomarkers to detect pre-malignant lesions in gastric corpus(Wiley-Blackwell, 2016) ;Tan, HL ;Ngiu, CS ;Mahmud, NRKN ;Naidu, J ;Rani, RA ;Elias, MH ;Moktar, NM ;Hamid, NAAli, RAR - Some of the metrics are blocked by yourconsent settings
Publication Comparison of access to medicines between Klang Valley and East Coast of peninsular Malaysia for children living in poor households(Pharmacotherapy Group, 2016) ;Saiful, A ;Ithnin, M ;Rani, MDM ;Noh, NA ;Hamid, NA ;Mohamed, IN ;Al-Naggar, RAripin, KNBPurpose: To compare access to medicines in children living in poor households (income of USD1/person/day) between urbanised Klang Valley and rural East Coast of Peninsular Malaysia. Methods: A semi-structured interview was conducted with caregivers to determine demographics, access to medicines, knowledge, attitude and practice of parents in obtaining medicines for children. Results: There was no significant difference socio-demographically between poor households in Klang Valley (N = 58) and East Coast (N = 40). The study found that access to medicine for children (N = 325) in the households was adequate, where all households that reported illness in the children over the last 1 month and the last 6 month periods, obtained medicines and 99 % of the children were fully immunized. Qualitative analysis showed that poor households face several barriers in accessing medicines for their children such as financial, transportation, physical and attitudinal. Conclusion: Access to medicines for children living in poor households in both areas were similar and adequate. However, barriers to access remain and further studies are required. - Some of the metrics are blocked by yourconsent settings
Publication Exploring The Dichotomy Of Transcranial Magnetic Stimulation's Frequencies On Brain Wave Patterns(Penerbit Utm Press, 2016) ;Noh, NA ;Mokhtar, A ;Hamid, NA ;Rani, MDMShamaan, NADisturbance in brain oscillations is observed in many neuropsychiatric disorders. Any tool that has the potential to restore abnormal brain oscillations is therefore beneficial to patients with neuropsychiatric illnesses. Repetitive transcranial magnetic stimulation (rTMS) is one such tool. It is a non-invasive brain stimulation technique, which is able to alter brain oscillations depending on its parameters of stimulation and is used in clinical setting because of its potential therapeutic effects on the brain. However, the optimum stimulation parameters to induce the therapeutic effect of rTMS remains elusive. Therefore, it is important to investigate the differential effects between high versus low frequency of magnetic stimulation on the mechanism of brain oscillations in human subjects. Here we show, using combined rTMS and surface electroencephalography (EEG) that low and high frequencies of magnetic stimulation would induce dichotomy effects in EEG brain oscillatory activity. In particular, high-frequency rTMS 10Hz induces a synchronised oscillations for theta brain rhythm. In contrast, low-frequency rTMS 1Hz desynchronises neural oscillations on the same brain rhythm. Taken together, our results show that the desynchronisation effect of low-frequency rTMS 1Hz may potentially reverse the interference of altered neural oscillations. More extensive basic and clinical research using combined rTMS and EEG are needed to determine the optimum parameters of rTMS stimulation to restore adequate neural oscillations. - Some of the metrics are blocked by yourconsent settings
Publication Serum pepsinogen and gastrin-17 as potential biomarkers for pre-malignant lesions in the gastric corpus(Spandidos Publ Ltd, 2017) ;Loong, TH ;Soon, NC ;Mahmud, NRKN ;Naidu, J ;Rani, RA ;Hamid, NA ;Elias, MH ;Rose, IM ;Tamil, A ;Mokhtar, NMAli, RARThere is a lack of non-invasive screening modalities to diagnose chronic atrophic gastritis (CAG) and intestinal metaplasia (IM). Thus, the aim of the present study was to determine the sensitivity and specificity of serum pepsinogen I (PGI), PGI: II, the PGI: II ratio and gastrin-17 (G-17) in diagnosing CAG and IM, and the correlations between these serum biomarkers and pre-malignant gastric lesions. A cross-sectional study of 72 patients (82% of the calculated sample size) who underwent oesophagealgastro-duodenos-copy for dyspepsia was performed in the present study. The mean age of the participants was 56.2 +/- 16.2 years. Serum PGI: I, PGI: II, G-17 and Helicobacter pylori antibody levels were measured by enzyme-linked immunosorbent assay. Median levels of PGI: I, PGI: II, the PGI: II ratio and G-17 for were 129.9 mu g/l, 10.3 mu g/l, 14.7 and 4.4 pmol/l, respectively. Subjects with corpus CAG/IM exhibited a significantly lower PGI: II ratio (7.2) compared with the control group (15.7; P< 0.001). Histological CAG and IM correlated well with the serum PGI: II ratio (r=-0.417; P<0.001). The cut-off value of the PGI: II ratio of <= 10.0 demonstrated high sensitivity (83.3%), specificity (77.9%) and area under the receiver operating characteristic curve of 0.902 in detecting the two conditions. However, the sensitivity was particularly low at a ratio of <= 3.0. The serum PGI: II ratio is a sensitive and specific marker to diagnose corpus CAG/IM, but at a high cut-off value. This ratio may potentially be used as an outpatient, non-invasive biomarker for detecting corpus CAG/IM.