This article described the urgency of strengthening digital literacy for santris as an exertion for doing online de-radicalization. As a santri should be core actors in a lot of idea competitions on social media, they should be provided both soft and hard skills in digitizing technology, especially dealing with information media. A Santri should be resourceful in presenting contents carrying the theme of the mercy of Islam and taking a strategic role in online de-radicalization. Five steps should be taken by pesantren in strengthening the digital literacy for santris, namely providing supporting infrastructure in the form of computer laboratories and internet networks, regulating restrictions on the use of the internet only for positive things, giving mentors and supervisors, holding blogging and positive content workshops, and supporting santris in the process of understanding Islamic literature (books of turas). Those were aimed to make santris could provide good content. This research was a qualitative study using a literature method that analyzed the literature and sources related to the research theme.