Browsing by Author "Jalil Kader"
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Publication Study On Anti-quorum Sensing Potential Of Selected Local Ulam In Malaysia(World Journal of Pharmacy and Pharmaceutical Sciences, 2014) ;Nur Aishah Abdul Wahab ;Mohd Syazwan Mohd Zain ;Jalil Kader ;Salina Mat RadziHanina Mohd NoorBacterial intercellular communication, or quorum sensing (QS), controls the pathogenesis of many medically important organisms. Anti-QS compounds have the ability to attenuate bacterial pathogenicity. The current quest for new antimicrobials aimed at discovering non-toxic inhibitors of QS from natural sources which can be used for the treatment of bacterial infections in human. The objective of this research is to study the anti-QS potential in some of local ulam commonly found in Malaysia. In this study, seven types of local ulam namely; Parkia speciosa, Cosmos cardatus, Centella asiatica, Manihot esculenta leaf sprigs, Psophocarpus tetragonolobus, Polygonum minus and Oenanthe javanica were tested on the anti-QS potentials in fresh (edible or macerated) forms and methanol extracts via biomonitor strain Chromabacterium violaceum ATCC 12472. This biomonitor strain has an ability to produce a purple pigment (violacein) under QS-control. The results exhibited the wide variation in the anti-QS activities on selected local ulam in fresh and methanol extract forms. The highest anti-QS activity was recorded by P. minus and C. asiatica extracts as the lowest of minimum QS inhibition concentration value (7.81 mg/ml) was indicated by both extracts respectively. This study introduces not only a new mode of action and possible validation for traditional plant use, but also a potentially new therapeutic direction for the treatment of bacterial infections. - Some of the metrics are blocked by yourconsent settings
Publication Study on anti-quorum sensing potentials and phytochemical constituents of Euphorbia hirta(International Institute for Science, Technology and Education, 2014) ;Nur Aishah Abdul Wahab ;Hanina Mohd Noor ;Salina Mat RadziJalil KaderEuphorbia hirta is an annual broad-leaved herb and widely used as traditional medicine to treat various ailments. This herb was tested on the anti quorum sensing (anti-QS) potentials in fresh (edible or macerated) forms and acetone extracts via biomonitor strain Chromabacterium violaceum (ATCC 12472). The biomonitor strain has an ability to produce purple pigment (violacein) under QS-control. The different parts of E. hirta extracts were then subjected to preliminary phytochemical screening using standard procedures and finally analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). Preliminary screening on fresh parts of this herb revealed that leaves exhibited the highest anti-QS activities towards C. violaceum. The results also exhibited the wide variation in the anti-QS activities on whole plants, flowers, stems, leaves and roots of E. hirta from acetone extraction. The highest anti-QS activities were recorded by leaves and flowers extracts as the lowest of minimum QS inhibition concentration values (1.8906 mg/ml) were indicated by both extracts respectively. Phytochemical screening of E. hirta extracts revealed the presence of carbohydrates, lipids, protein, flavonoids, alkaloids, saponins, resins, steroids, acidic compounds, tannins, glycosides, phenols and terpenoids. The quantitave phytochemical assays via GC-MS indicated that this herb rich with fatty acids, terpenoids and phenolic compounds.