Browsing by Author "Jumal J."
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Publication (±)-1,2-Bis(N′-benzoylthioureido)cyclohexane(2011) ;Jumal J. ;Ibrahim A.R. ;Yamin B.M. ;Faculty of Science and Technology ;Universiti Sains Islam Malaysia (USIM) ;Universiti Sains Malaysia (USM)Universiti Kebangsaan Malaysia (UKM)In the title compound, C22H24N4O 2S2, the two thiourea segments of the side-arm groups are inclined at a dihedral angle of 73.09 (9)°. The central cyclohexane bridge adopts a chair conformation. The molecule is stabilized by N-H⋯O intramolecular hydrogen bonds forming S(6) rings, and N-H⋯O and N-H⋯S intermolecular hydrogen bonds forming infinite chains developing parallel to the b axis. - Some of the metrics are blocked by yourconsent settings
Publication Differentiation of edible fats from selected sources after heating treatments using fourier transform infrared spectroscopy (FTIR) and multivariate analysis(American Institute of Physics Inc., 2018) ;Salleh N.A.M. ;Hassan M.S. ;Jumal J. ;Harun F.W. ;Jaafar M.Z. ;Institute of Halal Research and Management (IHRAM) ;Faculty of Science and Technology ;Universiti Sains Islam Malaysia (USIM)Universiti Teknologi MARA (UiTM)Lard consumption is forbidden for Muslim people and researches have been done to differentiate lard from other fats for Halal authentication. Therefore, this study was conducted to differentiate lard from other edible fats after heating treatments using Fourier transformed infrared spectroscopy (FTIR) and multivariate data analysis techniques. Five samples of fats from different sources; lard, chicken, mutton, tallow and palm based shortening were heated at different temperature (120, 180 and 240°C) and time (30, 60, 120 and 180 min). The spectra in the form of multivariate data were acquired using FTIR spectroscopy. Principal components analysis (PCA), k-mean cluster analysis (k-mean CA) and linear discriminant analysis (LDA) were used to compare the ability of each technique to differentiate the fats after the heating treatments. It was found that the combination of PCA with k-mean CA was able to differentiate heated fats according to its origin. LDA method was successfully used to classify 80.5 % of samples in its group. Thus, PCA, CA and LDA can be used as multivariate data analysis to differentiate the heated edible fats. - Some of the metrics are blocked by yourconsent settings
Publication Immobilization of enzyme using natural feldspar for use in the synthesis of oleyl oleate(American Institute of Physics Inc., 2018) ;Ali B.J. ;Othman S.S. ;Harun F.W. ;Jumal J. ;Rahman M.B.A. ;Faculty of Science and Technology ;Institute of Halal Research and Management (IHRAM) ;Universiti Sains Islam Malaysia (USIM)Universiti Putra Malaysia (UPM)Natural feldspar from Tanah Putih, Gua Musang, Kelantan (Malaysia) was physico-chemically characterized using X-ray Diffraction (XRD), Surface Area and Porosity Analysis (ASAP) and Energy Dispersive X-ray (EDX) techniques. The feldspar was found to be of the potassium (K) type, with major components containing aluminum (Al), and silicon (Si). The feldspar also possesses 38.307 nm mean pore diameter and 18.717 m2/g surface area. Candida rugosa (CRL) was then immobilized onto natural feldspar by physical adsorption method. About 49.96% of protein content was immobilized onto the support. The catalytic activity of the immobilized lipase was determined by the esterification reaction using oleic acid and oleyl alcohol. The effects of various reaction temperatures, stability in organic solvent, and lipase recyclability on the esterification reaction for the native and immobilized lipase were investigated. Feldspar-immobilized lipase exhibited higher activity than that of the native lipase. Immobilized lipase retained its activity ca. 50% even after incubation at high temperature (70°C) with the optimum reaction temperature of 40°C, long incubation in hexane up to 10 days and after ten repeated cycles used. Feldspar-immobilized lipase also showed considerably efficient reusability where it was not easily leached even after being washed with large amount of hexane (20 mL). These results showed that physical adsorption method is suitable for the immobilization of lipase onto feldspar. - Some of the metrics are blocked by yourconsent settings
Publication Liquid polymeric membrane composition of ion selective electrode based on thiazole-4-carboxamide as ionophore(American Institute of Physics Inc., 2019) ;Jamil N.W.Z. ;Yahya M.Z.A. ;Jumal J. ;Kasim N.A.M. ;Faculty of Science and Technology ;Universiti Pertahanan Nasional Malaysia (UPNM)Universiti Sains Islam Malaysia (USIM)Thiazole-4-carboxamide (Th) has been prepared as ionophore in an electrochemical setup of a cadmium ion selective electrode (ISE). There are four components in liquid polymeric membrane consist of thiazole-4-carboxamide (Th) as an ionophore, polyvinyl chloride (PVC) as a polymeric matrix, sodium tetra phenyl borate (NaTPB) as an ionic additive and benzyl acetate (BA) as a plasticizer. An experiment is conducted using various different composition of the membrane. Result shows the optimum ratio of Th:PVC:NaTPB:BA is 5.0:30.0:2.0:63.0 by weight percentage. The Nernstian response for Cd 2+ that obtained the best response at a range pH 5.20-5.72 is having a slope of 29.4�1.1mV per decade with a linear working range 1.0�10 -7 to 1.0�10 -4 . However, the worst Nernstian response for Cd 2+ at the same range of pH is having a slope of 15.7�0.6mV per decade with linear working range of 1.0�10 -4 to 1.0�10 -2 and using 0.0:33.0:2.0:65.0 as a ratio of Th:PVC:NaTPB:BA by weight percentage. � 2019 Author(s). - Some of the metrics are blocked by yourconsent settings
Publication Synthesis and biological evaluation of 6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo) coumarin(Science Publications, 2015) ;Ibrahim D.M. ;Jumal J. ;Harun F.W. ;Faculty of Science and TechnologyUniversiti Sains Islam Malaysia (USIM)6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo)coumarin has been synthesized and characterized by CHN elemental analysis, FTIR,1H-NMR-spectroscopy and mass-spectral data. Cytotoxic screening by MTT assay was carried out on the compound against breast cancer cells. The overall results from preliminary screening program revealed that the cell proliferation was highly inhibited by 6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo) coumarin with the value of 2.81%, at concentration of 30 ?g mL?1 compared with the untreated control cells and also possessed a good chelating activity with IC50 value 1.87 ?g mL?1. It is suggested that the cytotoxic activity is affected by hydroxyl and halogen groups as these groups have high electron affinity and high electronegativity. � 2016 Dalal M. Ibrahim, Juliana Jumal and Farah Wahida Harun. - Some of the metrics are blocked by yourconsent settings
Publication Synthesis and corrosion inhibition studies of 1-(4-chlorobenzoyl)thiourea derivatives on mild steel in 1.0 M HCL(American Scientific Publishers, 2017) ;Hashim S.N.M. ;Jumal J. ;Kassim K. ;Faculty of Science and Technology ;Universiti Sains Islam Malaysia (USIM)Universiti Teknologi MARA (UiTM)Three compounds of benzoylthiourea derivatives namely: 1-(4-chlorobenzoyl)-3-(4-fluorophenyl)thiourea (T1), 1-(4-chlorobenzoyl)-3-(3-chloro-2-fluorophenyl)thiourea (T2), and 1-(4-chlorobenzoyl)-3-(6-chloro-2-fluoro-3- methoxyphenyl)thiourea (T3), were successfully synthesized and characterized via micro elemental analyser, Fourier Transform Infra Red (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy methods. From the FTIR spectral data, the compounds are common to have the vibration frequency of stretching of v(N�H) around 3500�3100 cm?1, v(C=O) around 1660�1720 cm?1, v(C=S) around 680�1440 cm?1 and v(C=N) in the range 1350�1000 cm?1. The inhibition property of the resulted compound on the corrosion of mild steel in 1.0 M hydrochloric acid has been investigated at room temperature using weight loss measurement and linear polarization resistance technique. The inhibition efficiency obtained from both methods are in good agreement with one another. It was found that the inhibition efficiency increases with inhibitor concentration and maximum efficiency was obtained at 0.0004 M. Among the studied inhibitors, T3 shows the best inhibition efficiency of greater than 90%. The potentiodynamic study also reveals that the compounds studied acts essentially as mixed type inhibitor. � 2017 American Scientific Publishers All rights reserved. - Some of the metrics are blocked by yourconsent settings
Publication Synthesis and cytotoxic activity of 6-hydroxy-4-methyl-5,7-(bis-phenylazo) coumarin with divalent transition metal ions(Indian Society for Education and Environment, 2016) ;Ibrahim D.M. ;Jumal J. ;Harun F.W. ;Faculty of Science and TechnologyUniversiti Sains Islam Malaysia (USIM)Background/Objectives: One of the severe disease intimidating human health and continues to be a main health problem worldwide is cancer. Hence, discovering new compounds with powerful anticancer activity is of extreme important. The main objective of this paper is the synthesize 6-hydroxy-4-methyl-5,7-(bis-phenylazo) coumarin and its complexes and evaluate the cytotoxic activity of the ligand and complexes against breast cancer cells. Methods/Statistical Analysis: A novel compounds of 6-hydroxy-4-methyl-5,7-(bis-phenylazo) coumarin have been synthesized by 6-hydroxy-4-methylcoumarin. The complexation of nickel (II), copper (II) and cobalt (II) using this ligand gave salt type complexes with the formula of M(C22H15O3N4) the compounds were characterized by microelemental analysis, infra-red, nuclear magnetic resonance spectroscopic techniques and molar conductivity. Cytotoxic activity for the ligand and the complexes were evaluated against breast cancer cells by using MTT assay and the absorbance at 570 nm was measured by ELISA reader. Findings: The CHN analysis of the compounds are in good agreement with the calculated values and the spectroscopic analysis of the complexes indicated that the ligand coordinated to the metal centres as polydentate ligand in bisazocoumarin and form a distorted octahedral arrangement around nickel (II), copper (II) and cobalt (II) centres. The molar conductivity of the divalent metal ions complexes was small which directly supports the fact that all of the investigated complexes are non ionic. The overall results of cells MCF7 breast cancer revealed of cell proliferation was much more highly inhibited by the ligand and complexes Cu, Co and Ni with cell viability 5.21%, 17.36%, 46.20% and 74.43%, respectively at a concentration of 30 mg/ml compared to untreated control cells and IC50 values of the ligands and complexes of Cu, Co and Ni were 1.87, 1.87, 30 and >30 g/ml, respectively. Improvements: Lastly, some suggestions were presented to use these compounds in vivo should be assessed to obtain worthy anticancer drugs. - Some of the metrics are blocked by yourconsent settings
Publication Synthesis and radical scavenging activity of 6-hydroxyl-4-methylcoumarin and its derivatives(American Institute of Physics Inc., 2018) ;Jumal J. ;Ayomide A.F. ;Faculty of Science and TechnologyUniversiti Sains Islam Malaysia (USIM)Four compounds of coumarin derivatives namely 6-hydroxyl-4-methylcoumarin (I), 6-hydroxyl-4-methyl-5-(p-nitrophenyl azocoumarin) (II), 6-hydroxyl-4-methyl-5,7-(bis-p-nitrophenyl azocoumarin) (III) and 6-hydroxyl-4-methyl-5,7-(bis-p-chlorophenyl azocoumarin) (IV) were successfully synthesized. These compounds were prepared by reacting hydroquinone with ethylacetoacetate and selected anilines which are chloro and nitro aniline. All synthesized compounds were characterized by CHN micro-elemental analysis, 1H Nuclear Magnetic Resonance (NMR) and Fourier Transform Infrared (FTIR) spectroscopic methods. The infrared spectra of these compounds exhibited five important stretching vibrations: ?(-OH), ?(C=O), ?(C=C), ?(C-O) and ?(C-N) at 3441-3359 cm-1, 1604-1632 cm-1, 1581-1496 cm-1, 1331-1225 cm-1, 1251-1109 cm-1, respectively. 1H NMR spectra of these compounds show the presence of proton aromatic, proton methyl and proton pyrone ring with the chemical shift at ?H 7.00-8.70 ppm, ?H 2.20-2.50 ppm and ?H 6.10-6.90 ppm, respectively. CHN analysis results of all compounds are in good agreement with the calculated values. All the synthesized compounds were evaluated for their antioxidant activity using DPPH method and ascorbic acid used as the standard. UV-Vis spectroscopic technique was used to investigate the absorbance of these compounds. Compound (II) shows high antioxidant activities compared to compound (I), (III) and (IV) which show moderate to low activities. � 2018 Author(s).