Cervical cancer refers to a dangerous and common illness that impacts women worldwide. Moreover, this cancer affects over 300,000 people each year, with one woman diagnosed every minute. It affects over 0.5 million women annually, leading to over 0.3 million deaths. Recently, considerable literature has grown around developing technologies to detect cervical cancer cells in women. Previously, a cervical cancer diagnosis was made manually, which may result in a false positive or negative. Automated detection of cervical cancer and analysis method of the Papanicolaou (Pap) smear images are still debated among researchers. Thus, this paper reviewed several studies related to the detection method of Pap smear images focusing on Nuclei Segmentation and Deep Learning (DL) from the publication year of 2020, 2021, and 2022. Training, validation, and testing stages have all been the subject of study. However, there are still inadequacies in the current methodologies that have caused limitations to the proposed approaches by researchers. This study may inspire other researchers to view the proposed methods' potential and provide a decent foundation for developing and implementing new solutions.

Cervical cancer is regularly diagnosed in women all over the world. This cancer is the seventh most frequent cancer globally and the fourth most prevalent cancer among women. Automated and higher accuracy of cervical cancer classification methods are needed for the early diagnosis of cancer. In addition, this study has proved that routine Pap smears could enhance clinical outcomes by facilitating the early diagnosis of cervical cancer. Liquid-based cytology (LBC)/Pap smears for advanced cervical screening is a highly effective precancerous cell detection technology based on cell image analysis, where cells are classed as normal or abnormal. Computer-aided systems in medical imaging have benefited greatly from extraordinary developments in artificial intelligence (AI) technology. However, resource and computational cost constraints prevent the widespread use of AI-based automation-assisted cervical cancer screening systems. Hence, this paper reviewed the related studies that have been done by previous researchers related to the automation of cervical cancer classification based on machine learning. The objective of this study is to systematically review and analyses the current research on the classification of the cervical using machine learning. The literature that has been reviewed is indexed by Scopus and Web of Science. As a result, for the published paper access until October 2022, this study assessed past approaches for cervical cell classification based on machine learning applications