This article seeks to identify the relevant evidence found in the Quran on the relationship between franchisors and franchisees in the conduct of franchise business. It serves as a comprehensive guide throughout the agreement to limit conflicts that may deviate from achieving the goals of franchising While franchise is an industry model that comes with existing packages under the federal franchise act such as registration, training and marketing depending on the needs of their respective franchise companies. Therefore, this study describes the evidence in the Quran in relation to franchisors and franchisees relationship to make reference easier for certain angles. The qualitative methodology was applied in this study so that the objectives of the study were successfully fulfilled involving library research method by reading from various sources. The results show that the relationship between the two can be found in the Quran involving knowledge, obedience and help. This study suggests that the importance of maintaining relationships among franchise business owners is well understood based on the evidence from the first source of Islamic law and strive to fulfill every right of the parties involved.