Browsing by Author "Nadia Mohd Effendy"
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Publication Combined Effects Of Eurycoma Longifolia And Calcium On Bone Metabolism Of Orchidectomised Male Rats(Universiti Kebangsaan Malaysia, 2013) ;Nadia Mohd EffendyAhmad Nazrun ShuidOsteoporosis is characterized by low bone mass and destruction of bone microarchitecture. Androgen deficiency or hypogonadismisone of the major risk factors of osteoporosis in men. Testosterone replacement therapy (TRT) is the main treatment for hypogonadal osteoporosis but may cause side effects such as prostate cancer and cardiovascular diseases. An alternative treatment is required, with similar efficacy but minimal side effects. Eurycoma longifoliais a herbal plant that may have potential in treating osteoporosis, especial-ly if it is supplemented with calcium. This study was conducted to determine the combinational effects of Eurycoma longifoliaand cal-cium on the bone markers and biomechanical strength of orchidectomised male rats. A total of 48 rats were randomly divided into 6 groups; sham-operated control (SHAM), orchidectomised control (ORX), orchidectomised + 8mg/kg testosterone (TES), orchidecto-mised + 15mg/kg Eurycoma longifolia(EL), orchidectomised + 1% calcium (Ca) and orchidectomised + combination of 15mg/kg EL and 1% calcium (EL+Ca). Treatment was given for a period of 6 weeks and blood samples were taken prior and after the treatment to measure osteocalcin and CTX levels. The rats were euthanized after 6 weeks and femora were dissected for biomechanical analysis.The osteocalcin levels did not show any significant changes, while the CTX levels were significantly increased in the ORX group but de-creased in the other groups. The strain parameter of the EL+Ca was significantly lower than the EL group. In conclusion, single supple-mentation of EL was better than combination with calcium in terms of the bone remodeling and strength of orchidectomised rats. - Some of the metrics are blocked by yourconsent settings
Publication Comparison Of Health-seeking Behaviour Between Urban And Rural Malay Population Of Negeri Sembilan, Malaysia(JK Welfare & Pharmascope Foundation, 2019) ;Mohd Dzulkhairi Mohd Rani ;Muslimah Ithnin ;Nadeeya ‘Ayn Umaisara Mohamad Nor ;Norsham Juliana ;Nadia Mohd Effendy ;Sahar Azmani ;Khadijah Hasanah Binti Abang Abdullah ;Muhammad Shamsir Mohd ArisIzuddin Fahmy AbuThere is a growing interest on research related to health-seeking behaviours. However, there are minimal studies in Malaysia which focus on this issue. This paper aimed to determine the health-seeking behaviours among the Malay population and its association based on the localities of the urban and rural population. To achieve this purpose, a cross-sectional survey was conducted using face-to-face interview method. A total of 480 respondents participated in this survey with the majority (57.7%) of them were from a rural area. Among all the subjects, 4.9% and 5.4% of urban and rural participants respectively, did not seek treatment when they were sick. The reasons being are they chose to ignore the pain (80%), time-consumption (8%), and they do not believe in modern treatments (8%). A higher number of rural participants chose public healthcare facilities compared to urban (82.3% vs 72.6%, p<0.001), whereas a higher number of urban participants chose private healthcare facilities in contrast to rural participants (25.3% vs 16.4%, p<0.001). For participants with chronic diseases, 5.3% did not go for followup, 91.2% rely on healthcare staffs for information on the diseases, and 18.9% took traditional or supplementary medicine. Majority of the participants are in agreement that the accessibility to public healthcare facilities in terms of distance, transportation and operational time, as well as the services to get treatments, were good. Overall, majority of the respondents prefer to seek treatments from public healthcare facilities followed by private facilities and pharmacies. However, there is a small number of participants who did not seek for treatments, including those with chronic diseases. Further studies shall be conducted to explore the barriers to seeking treatments in this population. - Some of the metrics are blocked by yourconsent settings
Publication Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies(MDPI, 2023) ;Norsham Juliana ;Liyana Azmi ;Nadia Mohd Effendy ;Nur Islami Mohd Fahmi Teng ;Izuddin Fahmy Abu ;Nur Nabilah Abu Bakar ;Sahar Azmani ;Noor Anisah Abu Yazit ;Suhaini KadimanSrijit DasThe circadian system in the human body responds to daily environmental changes to optimise behaviour according to the biological clock and also influences various physiological processes. The suprachiasmatic nuclei are located in the anterior hypothalamus of the brain, and they synchronise to the 24 h light/dark cycle. Human physiological functions are highly dependent on the regulation of the internal circadian clock. Skeletal muscles comprise the largest collection of peripheral clocks in the human body. Both central and peripheral clocks regulate the interaction between the musculoskeletal system and energy metabolism. The skeletal muscle circadian clock plays a vital role in lipid and glucose metabolism. The pathogenesis of osteoporosis is related to an alteration in the circadian rhythm. In the present review, we discuss the disturbance of the circadian rhythm and its resultant effect on the musculoskeletal system. We also discuss the nutritional strategies that are potentially effective in maintaining the system’s homeostasis. Active collaborations between nutritionists and physiologists in the field of chronobiological and chrononutrition will further clarify these interactions. This review may be necessary for successful interventions in reducing morbidity and mortality resulting from musculoskeletal disturbances. - Some of the metrics are blocked by yourconsent settings
Publication The Effects Of Labisia Pumila On Postmenopausal Osteoporotic Rat Model: Dose And Time-dependent Micro-CT Analysis.(IOS Press, 2014) ;Nadia Mohd Effendy ;Mohd Fadhli Khamis ;Ima Nirwana SoelaimanAhmad Nazrun ShuidAbstract: BACKGROUND: Postmenopausal osteoporosis is best treated and prevented by estrogen replacement therapy (ERT). Although effective, ERT may cause breast cancer, uterine cancer and cardiovascular problems. Labisia pumila var. alata (LP), a herb with phytoestrogenic, antioxidative and anti-inflammatory effects has potential as an ERT alternative. OBJECTIVE: This study aimed to evaluate micro-CT analysis on the effects of LP supplementation on the trabecular microarchitecture of postmenopausal osteoporosis rat model. Micro-CT is an effective tool in detecting changes in trabecular bone structure and providing a three dimensional information which may replace other conventional bone analysis methods. METHODS: Ninety-six female Sprague-Dawley rats (4 to 5 months old) were randomly divided into six groups of baseline group (BL) Sham-operated (Sham), ovariectomised control (OVXC), ovariectomised with 64.5 μg/kg of Premarin (ERT), ovariectomised with 20 mg/kg of LP (LP20) and ovariectomised with 100 mg/kg of LP at (LP100). The vehicle (deionized water), Premarin and LP were given via daily oral gavages for three, six and nine weeks of treatment periods. Rats in BL group were euthanized before the start of the study, while other rats were euthanized after completion of their treatments. Femora were dissected out and trabecular bone microarchitecture analysed with micro-CT. RESULTS: Micro-CT analysis of OVXC rats revealed significant osteoporotic changes in connectivity density, trabecular bone volume, trabecular thickness, trabecular separation and trabecular number. Both ERT and LP were able to reverse all the OVX-induced bone changes with the best results seen with 100 mg/kg of LP for nine weeks duration of treatment. CONCLUSION: Micro-CT provides accurate and reliable information on trabecular bone parameters which aid in the diagnosis and treatment of osteoporosis. LP supplementation at 100 mg/kg was more effective than ERT in reversing ovariectomy-induced bone changes. Further studies are required to explore the potential of LP as ERT alternative in the treatment and prevention of postmenopausal osteoporosis. - Some of the metrics are blocked by yourconsent settings
Publication The Effects Of Tualang Honey On Bone Metabolism Of Postmenopausal Women.(Hindawi Publishing Corporation, 2012) ;Nadia Mohd Effendy ;Norazlina Mohamed ;Norliza Muhammad ;Isa Naina MohamadAhmad Nazrun ShuidOsteoporosis which is characterized by low bone mass and microarchitectural deterioration with a consequent increase in bone fragility can be associated with various stimuli such as oxidative stress and inflammation. Postmenopausal women are more prone to osteoporosis due to reduction in estrogen which may further lead to elevation of oxidative stress and lipid accumulation which will promote osteoblasts apoptosis. Proinflammatory cytokines are elevated following estrogen deficiency. These cytokines are important determinants of osteoclasts differentiation and its bone resorption activity. The main treatment for postmenopausal osteoporosis is estrogen replacement therapy (ERT). Despite its effectiveness, ERT, however, can cause many adverse effects. Therefore, alternative treatment that is rich in antioxidant and can exert an anti-inflammatory effect can be given to replace the conventional ERT. Tualang honey is one of the best options available as it contains antioxidant as well as exerting anti-inflammatory effect which can act as a free radical scavenger, reducing the oxidative stress level as well as inhibiting proinflammatory cytokine. This will result in survival of osteoblasts, reduced osteoclastogenic activity, and consequently, reduce bone loss. Hence, Tualang honey can be used as an alternative treatment of postmenopausal osteoporosis with minimal side effects. - Some of the metrics are blocked by yourconsent settings
Publication Eurycoma Longifolia Upregulates Osteoprotegerin Gene Expression In Androgen-deficient Osteoporosis Rat Model(BioMed Central Ltd., 2012) ;Nadia Mohd Effendy ;Ahmad Nazrun Shuid ;Eman El-arab ;Halimaton Saadiah Abdul Razak ;Norliza Muhammad ;Norazlina MohamedIma Nirwana SoelaimanBackground:Eurycoma longifolia(EL) has been shown recently to protect against bone calcium loss inorchidectomised rats, the model for androgen-deficient osteoporosis. The mechanism behind this is unclear but it may be related to its ability to elevate testosterone levels or it may directly affect bone remodeling. The aim of this study is to determine the mechanism involved by investigating the effects of EL extract on serum testosteronelevels, bone biomarkers, biomechanical strength and gene expression of Receptor Activator of Nuclear Factorkappa-B ligand (RANKL), Osteoprotegerin (OPG) and Macrophage-Colony Stimulating Factor (MCSF) inorchidectomised rats.Methods:Thirty-two male Sprague–Dawley rats were divided into: Sham-operated group (SHAM);orchidectomised-control group (ORX); orchidectomised and given 15 mg/kg EL extract (ORX + EL) andorchidectomised and given 8 mg/kg testosterone (ORX + T). The rats were treated for 6 weeks. The serum levels oftestosterone, osteocalcin and C-terminal telopeptide of type I collagen (CTX) were measured using the ELISA technique. The femoral bones were subjected to biomechanical testing. The tibial bone gene expressions of RANKL,OPG and MCSF were measured using the branch DNA technique.Results:The post-treatment level of testosterone was found to be significantly reduced by orchiectomy (p < 0.05).Both ORX + EL and ORX + T groups have significantly higher post-treatment testosterone levels compared to theirpre-treatment levels (p < 0.05). The bone resorption marker (CTx) was elevated after orchiectomy but was suppressed after treatment in the ORX + EL and ORX + T groups (p < 0.05). There was no significant finding for the femoral biomechanical parameters. The tibial OPG gene expression in the ORX group was significantly lower compared to the SHAM and ORX + EL groups (p < 0.05).Conclusion:Supplementation with EL extract elevated the testosterone levels, reduced the bone resorption markerand upregulated OPG gene expression of the orchidectomised rats. These actions may be responsible for the protective effects of EL extract against bone resorption due to androgen deficiency. - Some of the metrics are blocked by yourconsent settings
Publication Eurycoma Longifolia: Medicinal Plant In The Prevention And Treatment Of Male Osteoporosis Due To Androgen Deficiency(Hindawi Publishing Corporation, 2012) ;Nadia Mohd Effendy ;Norazlina Mohamed ;Norliza Muhammad ;Isa Naina MohamadAhmad Nazrun ShuidOsteoporosis in elderly men is now becoming an alarming health issue due to its relation with a higher mortality rate compared to osteoporosis in women. Androgen deficiency (hypogonadism) is one of the major factors of male osteoporosis and it can be treated with testosterone replacement therapy (TRT). However, one medicinal plant, Eurycoma longifolia Jack (EL), can be used as an alternative treatment to prevent and treat male osteoporosis without causing the side effects associated with TRT. EL exerts proandrogenic effects that enhance testosterone level, as well as stimulate osteoblast proliferation and osteoclast apoptosis. This will maintain bone remodelling activity and reduce bone loss. Phytochemical components of EL may also prevent osteoporosis via its antioxidative property. Hence, EL has the potential as a complementary treatment for male osteoporosis - Some of the metrics are blocked by yourconsent settings
Publication An Evidence-based Review Of Micro-CT Assessments Of The Postmenopausal Osteoporosis Rat Model(Asian Network for Scientific Information, 2015) ;Nadia Mohd Effendy ;Nurul Izzah Ibrahim ;Norazlina MohamedAhmad Nazrun ShuidMicro-CT (μCT) is a high resolution imaging tool that is generally used in animal studies. This review evaluates the effectiveness of μCT in assessing bone changes in the postmenopausal osteoporosis rat model. A systematic review of the literature was conducted to identify relevant studies on μCT and postmenopausal osteoporotic bone changes. A comprehensive search via the two databases; Medline via OVID Medline and Scopus was conducted for relevant studies published between 1994 and 2014. The results were limited to research articles published in English, that reported on the association between μCT findings and bone changes in the postmenopausal osteoporosis rat model. Studies were excluded if they were duplicated, did not use an ovariectomized-induced postmenopausal rat model and did not focus on μCT as the primary outcome. The literature search identified 182 potentially relevant articles that were later limited to 22 studies based on the inclusion and exclusion criteria. Fourteen in vitro μCT studies, 7 in vivo μCT studies and one report that combined both in vitro and in vivo μCT studies were included in this review. Of all these studies, 8 studies used μCT alone in assessing bone changes while the remaining studies used μCT analyses together with histomorphometry, DXA and pQCT which enabled a comparison of effectiveness. All the studies reported positive roles of μCT in evaluating bone quality. This evidence-based review highlights the ability of μCT to not only assess bone microarchitecture but also bone mineral density and bone strength. - Some of the metrics are blocked by yourconsent settings
Publication Factors Associated With Low Bone Density In Opioid Substitution Therapy Patients: A Systematic Review(Universiti Sains Islam Malaysia, 2021-01-01) ;Fitri Fareez Ramli, ;Syed Alhafiz Syed Hashim,Nadia Mohd EffendyBackground: Long-term opioid therapy is a risk factor for low bone mineral density (BMD). However, other factors may also contribute to low BMD. Several studies have examined the variables that might contribute to low BMD in patients receiving opioid replacement therapy (OST). However, to our knowledge, there was no systemic review conducted to address this particular issue. Thus, we reviewed the articles on the factors associated with low BMD in the population of opioid use disorder receiving substitution therapy. Methods: The articles that examined correlates or risk factors of low BMD in OST population were retrieved from OVID, SCOPUS, and PUBMED from inception until July 2020 by two independent investigators. Results: A total of 429 articles from three databases were retrieved initially. After screening based on eligibility criteria, five articles were included in the final analysis. The risk factors or correlates found to be significantly associated with low BMD in the OST population include male gender, low body mass index, low testosterone level, methadone or heroin use, and longer duration of heavy alcohol use. The review limitations include small sample sizes and inconsistent definition of variables. Conclusion: OST patients should be screened for BMD and its associated factors. Guidelines and training of practitioners involving in the OST service should be provided to increase the detection of low BMD in the OST population - Some of the metrics are blocked by yourconsent settings
Publication Ficus Carica (Fig), a Medicinal Prophetic Food(Research Updates in Medical Sciences, 2016)Nadia Mohd Effendy - Some of the metrics are blocked by yourconsent settings
Publication Health Seeking Behaviour Among Adult Orang Asli (Indigenous Peoples) From Rural Negeri Sembilan, Malaysia: A Mixed-methods Study.(Malaysian Public Health Physicians’ Association, 2021) ;Muslimah Ithnin ;Nadeeya'ayn Umaisara Binti Mohamad Nor ;Norsham Juliana Binti Nordin ;Nadia Mohd EffendyMohd Dzulkhairi Bin Mohd RaniGlobally, the minority indigenous peoples have a lower health status when compared with national populations. The Orang Asli who are indigenous peoples of Peninsular Malaysia, also poses a significant challenge towards the handling of diseases. The present study sought to synthesise a coherent explanation of health-seeking behaviour among Orang Asli using a mixed-method research approach. A cross-sectional survey was conducted among 324 adult Orang Asli living in the rural district of Jelebu, in the Peninsular Malaysian state of Negeri Sembilan who conformed to the inclusion criteria. Then, 16 participants were interviewed to obtain an in-depth insight regarding their health-seeking behaviour. The findings showed that the majority of the Orang Asli utilized modern healthcare facilities and the respondents reported that the accessibility, services and medicines provided by the government were excellent. Meanwhile, 40.7% of the respondents relied on both traditional and modern treatments. The key determinants of the modern health-seeking behaviours among the Orang Asli in this study were satisfaction on modern health, barriers in getting health services, acceptance and attitude, and traditional medicine utilisation. Government, institutions and healthcare facilities have a role in ensuring that the vulnerable Orang Asli population is not left behind in receiving essential information on diseases associated with chronic and infectious diseases, including the current COVID-19 pandemic, as their action of seeking treatment remains complex and multi-layered. - Some of the metrics are blocked by yourconsent settings
Publication The Knowledge, Attitude And Confidence On First Aid Response Among Childcare Providers Following FAT4CP© Training In Negeri Sembilan, Malaysia(JK Welfare & Pharmascope Foundation, 2019) ;Sahar Azmani ;Nadia Mohd Effendy ;Izuddin Fahmy Abu ;Faizul Helmi Addnan ;Mohd Radzniwan A Rashid ;Abd Rahman Hayati ;Che Ilina IsahakNorsham JulianaChildren daycare centres have nowadays become a necessity due to the guardians’ job constraint in this modern globalization era. Increasing demand of daycare centres showed ramiϑication on unintentional injuries at the childcare settings. The incidence is becoming more common and this may lead to a lawsuit for negligence. Failure to provide proper ϑirst aid response is one of the issues faced by the caregivers. To the best of our knowledge, this is the ϑirst study investigating the effects of ϑirst aid training and certiϑication on knowledge, attitude and conϑidence (KAC) among childcare providers in Negeri Sembilan, Malaysia. A self-administered questionnaire was given to 54 Negeri Sembilan childcare providers before and after they received a comprehensive module on the ϑirst aid training. The training comprised of three major components; basic life support, trauma injuries and non-trauma injuries. Throughout the training, participants were given a series of lectures, hands-on practicals and small group discussion on speciϑied topics from the module. Overall results showed a signiϑicant increase in knowledge, attitude and conϑidence (p<0.001) after the respondents’ had received the FAT4CP© training. The ϑirst aid training provided to the childcare providers was found effective and had successfully improved their knowledge by 12.5% and their conϑidence to perform ϑirst aid increased by 20.0%. They are now more prepared and efϑicient at handling any emergency situations at childcare centres. Our results suggested that FAT4CP© training programme was able to increase knowledge, attitude and conϑidence of childcare providers in Negeri Sembilan to handle emergency cases. Therefore, the programme is suggested to be implemented at all childcare centres in order to improve and sustain the providers’ abilities in handling emergency situations. - Some of the metrics are blocked by yourconsent settings
Publication Knowledge, Attitude, And Practices Of Non-communicable Diseases: Comparison Between Orang Asli And Malay From Rural Area In Negeri Sembilan, Malaysia: A Comparative Study(Malaysian Journal of Public Health Medicine (MJPHM), 2020) ;Muslimah Ithnin ;Norsham Juliana ;Nadeeya ‘Ayn Umaisara Mohamad Nor ;Nadia Mohd EffendyMohd Dzulkhairi Mohd RaniThe study evaluates the prevalence, knowledge, attitude, and practices of non-communicable diseases (NCDs) among adult Orang Asli and Malay ethnicity in Negeri Sembilan, Malaysia. This cross-sectional study involving 634 respondents aged 18 years and above of Orang Asli (51.3%) and Malays (48.7%) from the rural villages. Structured interview questionnaire for disease history and KAP level conducted. Weight, height, waist circumference, blood pressure, and blood glucose levels then measured. Prevalence of NCDs was higher among Malays compared to Orang Asli with hypertension (35.0% vs 14.8%), hypercholesterolemia (31.1% vs 5.2%), and diabetes mellitus (16.2% vs 4.3%), respectively. Malays also had a higher percentage of being abdominal obese (70.6% vs 59.7%) and increased blood pressure (54.4% vs 29.8%). Multivariate analysis indicates hypercholesterolemia [OR=6.035 (95%CI: 3.150,11.561)], abdominal obesity [aOR= 1.807 (95%CI: 1.065, 3.067)], and increased in blood pressure [aOR= 2.359 (95%C1: 1.619,3.437)] have a significant relation with Malay ethnicity. For Orang Asli, 51.7% had poor knowledge, 72.3% had a good attitude, and 16.0% had a good practice. Knowledge and attitude scores were significantly less among Orang Asli with no significant difference for practice compared to the Malays. The prevalence of NCDs among the Malays is alarmingly high, with an increasing trend among Orang Asli, which needs immediate attention. The NCDs and obesity were significant among Malays but also showed a worrying trend in the Orang Asli as the good practice on a healthy life-style was low in both ethnicities. Thus, proper education and promotion regarding NCDs needed for diseases screening and prevention. - Some of the metrics are blocked by yourconsent settings
Publication Metabolic Syndrome among Indigenous People (Orang Asli) in Peninsular Malaysia: A Systematic Review(Akademi Sains Malaysia, 2021) ;Muslimah Ithnin ;Khairun Nain Nor Aripin ;Nadia Mohd Effendy ;Norsham Juliana Binti Nordin ;Nadeeya'ayn Umaisara Binti Mohamad NorMohd Dzulkhairi Bin Mohd RaniMetabolic syndrome is a cluster of conditions that increase the risk of developing chronic diseases. This paper aims to assess the data on metabolic syndrome among indigenous Orang Asli in Malaysia. Searches were carried out using electronic databases of CINAHL, Medline, PubMed, and Scopus using predefined keywords. Cross-sectional studies of metabolic syndrome using any clinical diagnosis criteria among adult Orang Asli in Peninsular Malaysia included. Fifteen studies with these criteria were selected, five with metabolic syndrome studies. The general prevalence (weighted mean) of metabolic syndrome in Orang Asli was 26.3% (range: 12.0–39.8). Metabolic syndrome was more frequent in females (30.0%) than in males (19.3%). The most common components of metabolic syndrome were low HDL-C levels (41.0%) and hypertension (33.7%). For abdominal obesity, high triglycerides, and abnormal glycemia, the prevalence was; 24.6%, 21.5%, and 14.0%, respectively. Conclusively, the present systematic review brings us closer to an understanding of the prevalence of metabolic syndrome among this vulnerable population. The methodological differences among the studies published limit a joint analysis of their results. Nevertheless, finding from this review shows their high prevalence of the metabolic syndrome is comparable with other ethnic groups in Malaysia that requires immediate attention from all related parties. - Some of the metrics are blocked by yourconsent settings
Publication Time And Dose- Dependent Effects Of Labisia Pumila On The Bone Strength Of Postmenopausal Osteoporosis Rat Model(BioMed Central, 2015) ;Nadia Mohd Effendy ;Shahrum Abdullah ;Mohd Faridz Mod YunohAhmad Nazrun ShuidBackground: Post-menopausal osteoporosis has long been treated and prevented by estrogen replacement therapy (ERT). Despite its effectiveness, ERT is associated with serious adverse effects. Labisia pumila var. alata (LP) is a herb with potential as an alternative agent to ERT due to its phytoestrogenic, antioxidative and anti-inflammatory effects on bone. This study aimed to determine the effects of LP supplementation on bone biomechanical strength of postmenopausal osteoporosis rat model. Methods: Ninety-six female Sprague–Dawley rats aged 4 to 5 months old were randomly divided into six groups; six rats in the baseline group (BL) and eighteen rats in each group of; Sham- operated (Sham), ovariectomised control (OVXC) and ovariectomised with daily oral gavages of Premarin at 64.5 μg/kg (ERT), LP at 20 mg/kg (LP20) and LP at 100 mg/kg (LP100) respectively. These groups were subdivided into three, six and nine weeks of treatment periods. Rats in BL group were euthanized before the start of the study, while other rats were euthanized after completion of their treatments. Femora were dissected out for biomechanical strength analysis using Instron Universal Model 5848 Micro Tester. Results: OVXC group showed deterioration in the bone biomechanical strength with time. Both ERT and LP supplemented rats showed improvements in bone strength parameters such as maximum load, displacement, stiffness, stress, and Young Modulus. The most improved bone strength was seen in rats given LP at the dose of 100 mg/kg for nine weeks. Conclusion: LP supplementation at 100 mg/kg was more effective than ERT in reversing ovariectomy-induced bone biomechanical changes. - Some of the metrics are blocked by yourconsent settings
Publication Time And Dose-dependent Effects Of Labisia Pumila On Bone Oxidative Status Of Postmenopausal Osteoporosis Rat Model(MDPI, 2014) ;Nadia Mohd EffendyAhmad Nazrun ShuidPostmenopausal osteoporosis can be associated with oxidative stress and deterioration of antioxidant enzymes. It is mainly treated with estrogen replacement therapy (ERT). Although effective, ERT may cause adverse effects such as breast cancer and pulmonary embolism. Labisia pumila var. alata (LP), a herb used traditionally for women’s health was found to protect against estrogen-deficient osteoporosis. An extensive study was conducted in a postmenopausal osteoporosis rat model using several LP doses and duration of treatments to determine if anti-oxidative mechanisms were involved in its bone protective effects. Ninety-six female Sprague-Dawley rats were randomly divided into six groups; baseline group (BL), sham-operated (Sham), ovariectomised control (OVXC), ovariectomised (OVX) and given 64.5 μg/kg of Premarin (ERT), ovariectomised and given 20 mg/kg of LP (LP20) and ovariectomised and given 100 mg/kg of LP (LP100). The groups were further subdivided to receive their respective treatments via daily oral gavages for three, six or nine weeks of treatment periods. Following euthanization, the femora were dissected out for bone oxidative measurements which include superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA) levels. Results: The SOD levels of the sham-operated and all the treatment groups were significantly higher than the OVX groups at all treatment periods. The GPx level of ERT and LP100 groups at the 9th week of treatment were significantly higher than the baseline and OVX groups. MDA level of the OVX group was significantly higher than all the other groups at weeks 6 and 9. The LP20 and LP100 groups at the 9th week of treatment had significantly lower MDA levels than the ERT group. There were no significant differences between LP20 and LP100 for all parameters. Thus, LP supplementations at both doses, which showed the best results at 9 weeks, may reduce oxidative stress which in turn may prevent bone loss via its anti-oxidative property