Introduction: Massive chronic intervillositis (MCV) or currently known as chronic intervillositis of unknown aetiology is a rare poorly understood placental lesion. MCV is strongly associated with recurrent spontaneous miscarriages, IUGR and fetal demise. We described a case of MCV in a lady with consecutive recurrent miscarriages. Case report: The patient was a 37-year-old lady who had ten consecutive recurrent first trimester miscarriages within the last 13 years. She has no living child and the relevant blood investigations were not helpful in determining the cause of recurrent miscarriages. Histopathological examination of the conception tissues showed abundant aggregates of CD 68 positive histiocytes primarily within the intervillous spaces associated with increased perivillous fibrin deposition. No significant villitis were seen. The findings were consistent with massive chronic intervillositis. Discussion & conclusion: MCV is associated with high recurrence rate of spontaneous miscarriages. In general, practicing pathologist are unfamiliar with MCV. The histiocytes may be missed during a routine reporting of tissue from products of conception if important clinical informations are not being highlighted to the pathologists. Chronic intervillositis of infectious etiology should be excluded. However the etiology of MCV remains unclear. The histiocytes are maternal in origin which led to the hypothesis of a possible abnormal maternal immune reaction towards the placental tissue in the pathogenesis of MCV. Obstetricians and pathologists should be made aware of this entity. Until today, no proven effective treatment has been proposed to prevent recurrences. Further studies are required in the understanding of this entity and in the prevention of recurrent pregnancy losses.