Surgical extraction of the mandibular third molar is the most common surgical procedure in oral surgery clinic. Adequate postoperative instructions and good patient compliance are important to achieve positive clinical results and minimize complications. The objectives of the study were to determine the percentage of patient compliance towards postoperative care (POC) given by dental clinicians at USIM polyclinic and to identify the association between factors influencing patient compliance towards POC following the surgical extraction of mandibular third molar at USIM polyclinic and patient’s demographic characteristics. A set of questionnaires was disseminated to 16 patients which assessed the patients’ perception on swelling, bleeding, pain, diet, oral hygiene care, medication compliance, clinician’s factors, and patient’s level of understanding and their attitude towards POC. The percentages of patient compliance were represented by descriptive statistics, while the identification of possible factors influencing patient compliance were obtained by performing a Fisher Exact test. All factors give a high percentage of compliance which is more than 60% for all demographic characteristics. There is no association between all factors and demographic characteristics (p-value>0.05). Patient’s compliance is good and demographic characteristics do not appear to be key factors that ensure patient compliance towards POC following surgical extraction of the mandibular third molar.