Miswak (Salvadora Persica) has been used widely as oral aid since Babylonians era. Many methods have been introduced to improve the patient's denture hygiene but few researches on methods for cleaning edentulous area and denture to treat denture induced stomatitis. This study assessed the use of miswak stick to reduce denture induce stomatitis inflammation. A qualitative interview and questionnaires was conducted to assess the experience of miswak stick used 15 patients suffered from denture induced stomatitis. In addition, the inflammation areas were assessed using clinical photograph for the assessment of inflammation degree and denture stomatitis classification changes and compared with control group (using toothbrush). Four weeks’ result showed, no ulceration seen on the mucosa and edentulous arch. There was more than 50% (Mean=55.6%, SD±24.6%) reduction of inflammation surface area and redness. Patient with class 1 and 2 Newton's classification showed significant inflammation reduction more than 50% with 36.4% (Mean=20%, SD±9.9%) and 18.2% (Mean=20%, SD±9.9%). Patient also presented changes of the Newton's classification (n=26.7%). There is no significant different between using miswak vs conventional technique using toothbrush (p<0.05). Patients gave positive feedbacks of miswak on edentulous area as denture cleaning aid. In conclusion, miswak stick can be recommended as alternative oral care aid for edentulous patients and denture care. © 2020. All rights reserved.