Hand is the main organ used to manipulate the environment and to perform daily activities. Every human is endowed with a pair of right and left hands. A person's tendency to use the left or right hand can usually be clearly seen during childhood, which is from the age of two. Most children perform various activities and hold objects automatically with the right hand. However, there are a few individuals who are born with a tendency to use left-handedness. They feel that the left hand is stronger than the right hand and they are more comfortable to do many things. This group of individuals is called a recessive gene. The choice of hand use is based on a person's genetic variation. Previous studies have proven several factors that influence the preference of hand use such as environment, gender, and genes. The main purpose of this study is to analyse the genetic factors that influence the use of left-handedness on gifted and talented Muslim students at PERMATA Insan College. Based on the survey, the results show that majority of left-handed students have a family background of left-handedness and inherited from their parents. The advantage of left-handed individuals is that they have a high ability in the field of mathematics. Achievement of students understanding in Mathematics can produce Muslim scholars who are future-ready and excel in the field of Mathematical Sciences and increase their critical thinking ability.