Introduction: The preleukaemic and leukaemic diseases of infant and early childhood have been described. CL is a rare haematologic disease most often diagnosed at birth or within the first month of life and commonly are of acute myeloid leukaemias (AML). This however need to be differentiated from TAM of the newborn. We present a case and highlight challenges encountered in placental examination. Case report: A 35-year-old lady, in her fifth pregnancy presented at 40 weeks of gestation with absence in fetal movement. Further investigation confirmed an intrauterine death. Following induction of labour a male macerated stillborn was delivered. It was observed that the umbilical cord was short and the right testis was undescended. There were no associated syndromic features seen. The parents did not consent to a postmortem examination. The placenta was pale, foul smelling with meconium stains. Microscopically, there were numerous circulating immature precursors and nucleated red blood cells within the fetal vessels in the umbilical cord and chorionic villi. The morphology and immunohistochemistry were suggestive of a megakaryoblastic lineage. Discussion: Both AML and TAM are known manifestations in neonates with Down’s syndrome, predominantly involving the megakaryoblastic series. Although clinically and haematologically indistinguishable, TAM is transient and usually exhibits a spontaneous regression. However, with heart and liver involvement TAM may cause fetal demise. The underlying genetic contributions were not established in this case. However, both entities along with other neonatal leukaemoid and leucoerythroblastic conditions need to be considered. Hence detailed placental examination with relevant immunohistochemistry analysis is recommended.

Introduction: Actinomycosis is a chronic abscess-forming disease predominantly caused by Actinomyces israelii. Long-term use of an IUCD is known as a risk factor for pelvic actinomycosis. However the involvement of the abdominal wall is a rare clinical entity. We report an unusual case of abdominal actinomycosis presenting as abdominal wall intramuscular mass. Case: A 41- year-old lady para 3 presented with 3 months history of right iliac fossa pain associated with an infi ltrative abdominal wall mass. There was also associated loss of weight and appetite. Her white cell count was raised but there was no history of fever. She was on IUCD contraception for the past 3 years and her menses were otherwise regular. The mass was then excised in view of clinical and radiological suspicion of malignancy. The histopathological fi ndings of the mass showed presence of multiple abscesses containing Actinomyces colonies within the muscular wall and adjacent tissue, surrounded by chronic infl ammation and tissue fi brosis. She had her IUCD removed and was started with antibiotic therapy with serial CT scan surveillance. Conclusion: This case illustrates that actinomycoses can mimic the presentation of a malignancy only to be confi rmed histologically as an infection. Recognition of the various ways of presentation for Actinomyces is essential for appropriate management of the patients.

Introduction: Actinomycosis is a chronic progressive suppurative disease commonly caused by Actinomyces israelii. Abdominopelvic actinomycosis is rare and the appendix is the most common organ involved. Here, we would like to share a case of actinomycosis presented as acute appendicitis in a child. Case report: A 13-year-old boy presented with 5 days history of colicky periumbilical and right iliac fossa pain which was associated with fever and vomiting. He was febrile on examination. There was rebound tenderness on right iliac fossa. His blood count showed leucocytosis with neutrophils predominant. Acute appendicitis was suspected clinically and surgery was performed. Intraoperative findings showed an appendicular mass with localized abscess collections. The appendix was enlarged with macerated mesoappendix. Histology of the appendicular tissue showed acute appendicitis with dense suppurative inflammatory exudates seen in the outer appendicular wall, serosa and mesoappendix with abscess formation. Actinomyces colonies with typical sulphur granules and inflammatory exudate are seen in the lumen. Discussion and conclusion: Abdominopelvic actinomycosis may have resemblance to other disease such as acute appendicitis, diverticulitis or Crohn’s disease. However, histological examination would be able to distinguish them. A combination of long term antibiotic therapy and adequate surgery is necessary to ensure complete eradication. Actinomycosis should be included in the differential diagnosis, especially in patients with abdominal pain, fever, and leukocytosis.

Introduction: Uterine arteriovenous malformation (AVM) is a rare, potentially life-threatening condition. Because of the abnormal communication between arteries and vein, the high vascular flow may result in massive haemorrhage. We present an unexpected case of uterine AVM in a term pregnancy. Case report: A 35-year-old lady, G2P1 at 39 weeks of gestation, with a previous history of caesarian section, had a vacuum assisted delivery following poor maternal effort. There was light meconium stained liquor seen. However, she had to undergo an exploratory laporatomy due to a sudden worsening abdominal pain with symptomatic anaemia. Intraoperatively, there was a massive intraperitoneal collection of blood with intractable bleeding from a localized source in the left parametrium. Inevitably, a subtotal hysterectomy had to be performed. No tear nor disruption of the myometrial wall was identified. Serial sections of the uterine specimen showed groups of dilated spaces containing blood within the parametrial serosa. Histological sections demonstrated a mixture of vascular structures with walls of variable thickness consistent with an arteriovenous malformation. Discussion: Both congenital and acquired forms of uterine AVM have been described, the latter being associated with previous uterine trauma or caesarian section. Hormonal changes in a pregnancy such as in this case may play a role in endothelial proliferation and hence the increase in vascularity of the existing lesion in the uterus. Although embolization is the initial treatment option in selected patients, there can be emergency situations where hysterectomy remains the only choice.

Introduction: CMV (Cytomegalovirus) infection of the placenta may demonstrate the diagnostic viral inclusions and/or placental vilitis. Today, by immunohistochemistry, the CMV infected cells are easily identifi ed without having to scrutinise every villous to look for the inclusions. We might have even forgotten the beatiful nature of the owl’s eye inclusions. We would like to share an ordinary case of congenital CMV infection with these characteristic inclusions. Case: A 25 year old lady, in her second pregnancy presented with an intrauterine fetal death at 27 weeks gestation. There was no history of trauma, abdominal pain or pervaginal bleeding. Her fi rst son was born a year ago and is currently alive and well. The fetal scan shows IUGR (intrauterine growth restriction) with parameters of about 20 weeks gestation. With Prostin induction, she delivered a macerated stillborn. On histology, the placenta shows hydropic villi with scattered large cytomegalic cells with eosinophilic inclusions within the stroma. Some of them display the characteristic owl’s eye inclusions. On immunohistochemical staining, these inclusions are reactive to CMV antibody. Conclusion: CMV infection is one of the commonly occuring intrauterine infections. Recognizing the histopathological features may aid in identifying the cause of intrauterine death as many of these women are asymptomatic.

Introduction: Parvovirus B19 infection is a well-established cause of fetal death in hydrops fetalis. The diagnosis is usually made through histological identification of the characteristic nuclear inclusions in the placenta or fetal organs. However, the search for these inclusions are difficult at times particularly when placental sampling is limited or consent for fetal autopsy is not obtainable. We would like to share a case of congenital parvovirus infection with these characteristic inclusions and highlight the usefulness of immunohistochemistry. Case report: A 30-year-old lady, in her fourth pregnancy was referred for hydrops fetalis at 21 weeks gestation. She has three living children whom are currently well. Following induction of labour she delivered a male fetus. There were no dysmorphic features observed. However, the placenta was markedly large for gestational age, pale and friable with low fetoplacental ratio. On histology there were hydropic villi with increased nucleated red blood cells (RBC) within chorionic fetal vessels, many of which contained the characteristic intranuclear inclusions. They stained positively on immunostaining with parvovirus antibody. The parvovirus serology at the time of presentation was equivocal for IgM and positive for IgG. Other relevant microbiological investigations were negative. Discussion: Parvovirus infection is one of the commonly occurring intrauterine infections. Recognizing the histopathological features may aid in identifying the cause of intrauterine death as many of these women are asymptomatic. The use of immunostaining is very useful in confirming viral inclusions in the nucleated RBC and usually reveals a larger number of positive cells compared to H&E staining alone.

Phyllodes tumour and fibroadenoma are a group of biphasic breast lesions combining epithelial and stromal components. CD10 expression has long been recognized in haematological malignancies and is useful as a myoepithelial cell marker. Earlier studies suggested that CD10 expression in tumour stroma was associated with biological aggressiveness of a tumour. The study was done to assess stromal CD10 expression within the different grades of Phyllodes tumour and to evaluate whether stromal CD10 expression is associated with higher tumour grades.

Objective - Maintenance of bone marrow derived mesenchymal stem cells (BMMSC) numbers is important to preserve the balance required for normal tissue regeneration. 'Ajwa' date palm fruit, a popular Middle Eastern food, is known for its superior nutrition and medicinal properties. However, the direct effect of 'Ajwa' dates on stem cell biology remains unclean This study aims to investigate the potential effect of 'Ajwa' date palm fruit on BMMSC proliferation. Materials and methods - BMMSC were treated with different concentrations of aqueous extract of Ajwa' date palm fruit (mg mL(-1)). Proliferation, morphology, surface markers and gene expression of BMMSC were evaluated after the treatment. Results and discussion - 'Ajwa' date palm fruit significantly enhanced BMMSC proliferation and retained the sternness of BMMSC. Quantitative gene expression analysis demonstrated significant increase of proliferation related genes; beta-Catenin, C-Myc and HGF and lower expression of apoptotic genes; BAX and Caspase-3 and senescence-related gene, p21. Conclusion - These findings suggest the potential effect of 'Ajwa' date palm fruit as stem cell nutrition in the preservation of endogenous BMMSC for tissue regeneration.

Objectives: To establish the incidence of “diabetes-related death” (DRD) in children with known and unknown Diabetes Mellitus (DM) dying unexpectedly, and describe post-mortem (PM) biochemistry findings. Patients and Methods: PM reports from the previous 16-year period were reviewed. Cases of DRD were extracted. All available demographic, clinical, and autopsy data including laboratory analyses was retrieved. Results: 9/1376 (0.7%) DRD cases were identified. This was attributed to Diabetic Ketoacidosis in 7 and to Death in Bed Syndrome in 2. 4/9 cases were known diabetic and on insulin; whilst in 5/9 cases the diagnosis of DM was at PM. The mean age was 11.6 years (range 2.5–15). At PM, 4 cases were undernourished. The histology demonstrated pancreatic changes in keeping with DM in 3/9 and unremarkable pancreatic findings in 6/9. 3 cases also had autoimmune thyroiditis (1 also had myocarditis and Armanni-Ebstein nephropathy). Toxicological and biochemical analysis showed raised: β-hydroxybutyrate in 6, ketone bodies in 5 cases and raised HbA1c in 3c. Conclusion: Type 1 DM is an infrequent but yet potentially preventable cause of death in children. Our findings highlight the value of routine biochemical and toxicological analysis in all PM examinations of infants and children dying suddenly and unexpectedly.

BACKGROUND: Antiphospholipid syndrome (APS) is a multisystem disease that may present as venous or arterial thrombosis and/or pregnancy complications with the presence of antiphospholipid antibodies. Until today, heterogeneity of pathogenic mechanism fits well with various clinical manifestations. Moreover, previous studies have indicated that genes are differentially expressed between normal and in the disease state. Hence, this study systematically searched the literature on human gene expression that was differentially expressed in Obstetric APS.METHODOLOGY: Electronic search was performed until 31st March 2015 through PubMed and Embase databases; where the following Medical Subject Heading (MeSH) terms were used and they had been specified as the primary focus of the articles; gene, antiphospholipid, obstetric, and pregnancy in the title or abstract. From 502 studies retrieved from the search, only original publications that had performed gene expression analyses of human placental tissue that reported on differentially expressed gene in pregnancies with Obstetric APS were included. Two reviewers independently scrutinized the titles and the abstracts before examining the eligibility of studies that met the inclusion criteria. For each study; diagnostic criteria for APS, method for analysis, and the gene signature were extracted independently by two reviewers. The genes listed were further analysed with the DAVID and the KEGG pathways.RESULTS: Three eligible gene expression studies involving obstetric APS, comprising the datasets on gene expression, were identified. All three studies showed a reduction in transcript expression on PRL, STAT5, TF, DAF, ABCA1, and HBEGF in Obstetric APS. The high enrichment score for functionality in DAVID had been positive regulation of cell proliferation. Meanwhile, pertaining to the KEGG pathway, two pathways were associated with some of the listed genes, which were ErBb signalling pathway and JAK-STAT signalling pathway.CONCLUSION: Ultimately, studies on a genetic level have the potential to provide new insights into the regulation and to widen the basis for identification of changes in the mechanism of Obstetric APS. Keywords: antiphospholipid, gene, obstetric, pregnancy

Introduction: Liver biopsies are important to document any allograft rejection in liver transplantation. As one of the main centres providing liver transplant services, we are fortunate to experience dealing with liver allograft biopsies. Here, we briefl y describe our experience over a 7-year period. Materials and Methods: All reports of liver allograft biopsies performed from January 2004 to December 2010 in Hospital Selayang along with the relevant clinicopathological data were retrieved from the Department of Pathology archives using Cerner Pathnet Application. Results: There were 29 biopsies done from 18 patients aged between 19 months to 47 years old. Eleven of them were from males and 7 were female patients. There were 10 Malays, 5 were Chinese and 3 were Indians. Biliary atresia, Tyrosinaemia, Alagille’s syndrome and fulminant liver failure were some of the earlier indications or aetiologies for the liver transplantation. Most of them showed abnormal liver enzymes prior to allograft biopsy. The biopsies were evaluated using Banff scheme for liver allograft rejection. Ten (34.5%) of the cases showed acute rejection, 2 of the cases was indeterminate and another 2 cases showed chronic rejection. Fourteen (48.3%) of the cases showed no evidence of rejection. Drug induced injury, chronic biliary outfl ow obstruction, vanishing bile duct syndrome and chronic hepatitis were among the histopathological changes found in the allograft biopsies of these 14 cases. Conclusion: Liver biopsy is useful to evaluate graft dysfunction and to confi rm clinically suspected rejection. Adequate interpretation is dependent on adequacy of sampling, knowledge of differential diagnoses, clinical aspects of transplant hepatology and also close interaction with the clinical team.

Introduction: Maternal Floor Infarction (MFI) is an uncommon pathological entity characterised by the presence of massive and diffuse perivillous fibrinoid material in the maternal surface of the placenta. It was first described in the 1960s. MFI has clear associations with intrauterine fetal demise, IUGR and recurrent pregnancy losses. We would like to share two cases of MFI, which had similar clinical presentations. Case reports: Case 1: A 31-year-old lady who is in her sixth pregnancy and at 32 weeks of gestation. She has a history of three intrauterine fetal deaths and two live births. Her recent pregnancy was complicated with IUGR, oligohydramnious and absence of end diastolic flow on Doppler. Case 2: A 34-year-old lady who is in her third pregnancy and at 35 weeks of gestation. Similarly she had IUGR and oligohydramnios. In both cases, the babies were delivered alive by caesarean sections. Tissue examination of both placentas showed extensive fibrin deposition on the decidual floor, extending up into the intervillous spaces with encasement of the villi amounting to MFI. Discussion and Conclusion: Although MFI is uncommon, it has significant perinatal morbidity and mortality with the risk of recurrence. In general, practicing pathologists are unfamiliar with MFI which is macroscopically and microscopically different from ischaemic infarcts. The etiology of MFI is unknown, but evidence support an alloimmune or autoimmune mechanism. Awareness of this old entity and recognizing them on placenta tissue sections would aid in management of future pregnancies and in the adequate follow up of the surviving infants

Maintenance of bone marrow mesenchymal stem cells (BMMSC) numbers is crucial for tissue repair and regeneration since adult stem cells are often limited in number, expansion capacity and lifespan. It is believed that certain types of foods are beneficial in the preservation and stimulation of stem cells throughout life. Black seeds and stingless bee honey are among the widely investigated functional food with general health promoting benefit. We aim to explore the proliferative, anti-apoptosis and anti-senescence effect of Nigella sativa and Trigona honey on BMMSC. Cell proliferation was evaluated using MTT assay. We performed flow cytometric analysis to verify stem cell surface markers while quantitative PCR was done to measure the relative expression of target genes. Results showed favourable concentration dependent enhancement of cell proliferation by 1 to 10 ug/mL Nigella sativa and 0.097% to 0.195% Trigona honey. Observation on BMMSC’s morphology and surface markers expression revealed no alteration on BMMSC stemness properties. In addition, gene expression analysis supported that there was a significant (P<0.05) increase in proliferation related gene, β-Catenin, and lower expression of apoptotic- and senescence-related gene, BAX and p21, respectively. These preliminary findings suggest a promising effect of Nigella sativa and Trigona honey on stem cell proliferation.

Medical doctors’ work to prevent, diagnose, treat diseases, disorders, and injuries as well as prescribing medication. Many people are attracted to this profession because it gives them the opportunity to help others. Doctors’ improve quality of life by providing advice, healing physical ailments and performing complex surgeries. Medicine is a profession in which dedication to the wellbeing of others is of paramount importance. Balancing the requirements of work and personal life can be a struggle as the demand of work as a doctors’ is great. Perception and expectation of medical students regarding the lifestyle of doctors’ is important to ensure that they had made the right career choice. Thus, the aim of this study is to assess the perception of pre-clinical students regarding doctors’ lifestyle. This study is a cross-sectional study involving all third-year pre-clinical medical students at University Sains Islam Malaysia. A total of 81 students participated in this study. Participants were given a set of questionnaire consisting of demographic data, open-ended questions on their perception on doctors’ lifestyle of working environment, salary expectation and family life. Thematic analysis were used to analyse the data. The participants comprised 69% female and their age range was between 20-21 years old. Majority of them were from middle income families. Majority of the students perceived that the doctors’ lifestyle would be busy (72%). Approximately 30% of them expected that the time schedule will be unpredictable, 21% mentioned that sacrifice is required and 16% perceived it as a tiring job. Other themes emerged were ‘requiring high commitment’ (6%), challenging (7%) and risky (4%). With regards to salary expectation, 48% expected reasonable salary, 33% high salary and 12% described it as 'not worth compared to the workload'. Majority of them perceived that their family life will be restricted (62%) and time management is important (33%). Only 15% mentioned that family members have to sacrifice and spousal understanding is important (7%). About 10% of them perceived that their family will not be affected by their profession. Majority of the medical students perceived a busy doctors’ lifestyle, reasonable salary and restricted family life. However, there was a significant proportion of them who required counselling for better preparation of their future lifestyle.

Intrauterine infection has emerged to be the main and frequent cause of premature delivery and foetal demise. Microorganisms gain entry into the amniotic cavity via ascending route, haematogenous dissemination, retrograde seeding from peritoneal cavity and accidental introduction during invasive procedures. This is a case of foetal loss in utero from a twin pregnancy due to intrauterine sepsis diagnosed through placenta examination. Both maternal and foetal evidences of inflammatory response were demonstrated in the placenta on histology. Microscopically, there were acute chorioamnionitis and villitis as well as abundant gram positive cocci in the foetal blood within placental villous capillaries. The presence of intravascular bacterial organism provides evidence for a conclusive diagnosis of intrauterine sepsis, particularly where the placenta or foetal blood microbiological cultures results are not available or equivocal. More attention should therefore be given when sampling, as pathological evidences of underlying foetal compromise or death could be provided by well-represented placental tissue samples.

Introduction: Placental teratoma is an extremely rare benign non trophoblastic tumor of the placenta. It consists of various mature tissues derived from germ cell layers. We report a case of placental teratoma which was an unexpected finding during a normal per vagina delivery. Case report: The patient was a 35-year-old lady at full term gestation presented to the hospital with signs of labour. She had spontaneous vaginal delivery and her baby was well. However, following the delivery of the placenta she passed out an oval mass measuring approximately 7.5 cm in largest diameter with skin-like appearance of the outer surface. The cut surface of the mass appeared heterogenous with solid and cystic areas. On histology the cystic areas were lined by skin with an underlying adnexal tissue. The components of the solid areas were bony, cartilagenous and adipose tissues as well as brain, blood vessels and glands. No immature component was noted. The placenta tissue was unremarkable. Discussion and conclusion: The differential diagnosis is fetus acardius amorphus which is due to blighted fetus or failed twin associated with multiple pregnancy. On the contrary, placental teratoma is almost always associated with a normal pregnancy outcome and fetal development. Whether it is a true neoplasm or an extreme form of fetus acardius, the issue of origin remains unsolved. Obstetricians and pathologists should be made aware of this entity. In understanding the molecular insights of their histogenesis, further studies are required

Choosing a course to pursue is an important decision for students to make. A suitable career should correspond to the students' personalitiy for future work satisfaction and success. The objectives of this study were to determine the students' reasons for choosing medicine, their personality traits and aptitude (suitability). This was a cross-sectional study involving all third-year medical students at Universiti Sains Islam Malaysia. A self-administered questionnaire was used, which included questions on demographic data, Sidek Career Interest Inventory and reasons for choosing medicine. The inventory was used to measure the students' personality traits and career suitability. A total of 80 students participated in the study. Majority of them were females (n=56, 70.0%). The findings showed that 45.7% (n=44) of the repondents chose medicine because of 'passion and interest', while 24.7% (n=20) and 19.8% (n=16) because of 'parental influence' and 'to help the society', respectively. For medicine, two personality traits are essential which are investigative and social personality traits. Approximately, 47.5% (n=38) of the respondents had high scores in investigative personality trait. However, only 13.8% (n=11) of them had high scores in social personality trait. Only 12.5% (n=10) of the students had high scores when combining both of the traits. Majority of the students chose medicine for altruistic reasons. However, only a few of them had suitable aptitude for this course namely investigative and social skill. Therefore, the students and the teachers need to be aware of these issues and cultivate the required skills in the students for better career outcome.

Introduction: Antiphospholipid antibodies are autoantibodies that attack phospholipid through anti-b2-Glycoprotein-1. The actions by these antibodies are associated with various sites of thrombosis and pregnancy mobidity which is also known as the antiphospholipid sysdrome (APS). The pathogenesis of APS is still not elucidated. Recently, microRNA expressions in many types of diseased tissues have been identified and linked to the involvement in both pathology and progression of diseases. Therefore, a systematic review was performed to search the literature for research papers focusing on microRNA expression profile in APS. Methodology: An electronic search was performed till March 2015. Three search engines; EBCOHOST, PROQUEST AND OVID were used to identify literature related to expression of specific microRNA in APS. Two reviewers independently scrutinized titles and abstracts before examining the eligible of studies that met the inclusion criteria. A total of 350 papers were found and screened. Results: Only one study fulfilled the inclusion criteria. The microRNAs found to be associated with APS regulation were miR-19b and miR-20a. No data was found on specific microRNA expressed in obstetric antiphospholipid syndrome. Discussion: Limited data on expressions of microRNA in APS suggests that further research in this field is required. Conclusion: Characterization of microRNA profile in blood and also in placenta tissue of patients with APS could be a useful model to explain the regulation of certain genes involved.

Introduction: The most common indication for renal allograft biopsy is impaired renal allograft function and acute renal allograft dysfunction. The biopsy may also be part of post transplant renal biopsy protocols. Graft failure may be due to many causes, acute rejection being the most common. A retrospective study on renal allograft biopsies in Hospital Selayang was done to get an overview of the pattern of post transplant renal biopsy cases in the hospital. Materials and Methods: All histopathological reports of renal biopsies that were performed from January 2006 to March 2011 in Hospital Selayang along with the relevant clinicopathological data were retrieved from Department of Pathology archives using Cerner Pathnet Application. Results: Altogether there were 112 renal biopsies and these were obtained from 77 patients. The age range was 10 years to 68 years old, from 46 males and 31 females. Forty two percent of the cases (47/112) showed acute rejection changes either cellular, humoral, borderline or mixed categories. Acute cellular rejection was seen in 25/47 (53.2%) cases with most of them having tubulointerstitial rejection, Banff type 1. There were 19/47 (40.4%) cases showing borderline changes and 12/47 (25.5%) showing humoral rejection. Acute tubular necrosis was seen in 23/112 (20.5%) cases. Other changes seen are chronic allograft nephropathy, calcineurin inhibitor toxicity, pyelonephritis as well as infection with Polyoma virus and Cytomegalovirus. Conclusion: These fi ndings showed that rejection changes are the commonest entity emphasising the value of renal biopsy in post transplant patients. Appropriate management can be instituted effectively if early changes of rejection can be detected.

Choosing a career is one of the most important decisions in our life. A right career leads a person to grow with that career and achieve success through the decision. Thus, career suitability assessment is important to help individuals to understand how a variety of personal attributes can impact their potential success and satisfaction with different career options and work environments. Some career needs specific personality trait that relates to attributes of job requirements and commitments. For medicine, being caring, approachable, inquisitive, able to listen and understand patients’ pain, anxiety and sorrow are important. The aim of this study was to evaluate the career suitability of pre-clinical students. This was a cross sectional study conducted among pre-clinical medical students in Universiti Sains Islam Malaysia. 'Sidek Career Interest Inventory’ was used to assess the students’ suitability for the course. This instrument had been validated locally to suit the local social and cultural context. It assessed the students’ personality trait based on Holland’s theory and their interests. For students to pursue in the medical course, two main personality trait are believed to be essential namely investigative and social trait personalities. Some of the characteristics of investigative trait are analytical, rational, intellectual and curious, while the characteristics of social trait personality include empathy, friendly, understanding and accommodating. The score for each personality trait were categorized as low (0-3.99), moderate (4-6.99) and high (7-10). A total of 81 pre-clinical medical students were included in this study. About two third (93.8%) of them were female and all of them are from 20 to 21 of age. Approximately, half of the students (47.5%) scored high and another 46.3% scored moderate for investigative trait. For social trait, only 13.8% scored high while 31.3% scored moderate. Only 12.5% (10) students had high scores for both investigative and social traits. Most of the pre-clinical medical students scored high in the investigative sections, however their social values were inadequate (low scores). For them to become good medical doctors, they should be good in both investigative and social skills to enhance their suitability for this career. Therefore, there is a need to nurture these medical students with appropriate social values and soft skills.