Browsing by Author "Razaly N.I."
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Publication An Evidence-Based Review: The Effects of Malaysian Traditional Herbs on Osteoporotic Rat Models(Penerbit Universiti Sains Malaysia, 2018) ;Mohammad N.A. ;Razaly N.I. ;Mohd Rani M.D. ;Muhammad Shamsir Mohd Aris ;Nadia M.E. ;Faculty of Medicine and Health SciencesUniversiti Sains Islam Malaysia (USIM)Osteoporosis is considered a silent disease, the early symptoms of which often go unrecognised. Osteoporosis causes bone loss, reduces mineralised density, and inevitably leads to bone fracture. Hormonal deficiencies due to aging or drug induction are also frequently attributed to osteoporosis. Nevertheless, the phytochemical content of natural plants has been proven to significantly reduce osteoporotic conditions. A systematic review was conducted by this study to identify research specifically on the effects of Malaysian herbs such as Piper sarmentosum, Eurycoma longifolia and Labisia pumila on osteoporotic bone changes. This review consisted of a comprehensive search of five databases for the effects of specific herbs on osteoporotic bone change. These databases were Web of Science (WOS), Medline, Scopus, ScienceDirect and PubMed. The articles were selected throughout the years, were limited to the English language and fully documented. Duplication, irrelevant titles, different herbs and in vitro studies were excluded, including those that are not original research papers. A total of 399 potential studies were identified, but only 21 samples were accepted based on the inclusion and exclusion criteria. Six of the twenty one studies were on Piper sarmentosum, six on Eurycoma longifolia, and the remaining nine studies were on Labisia pumila. Overall, in three of the studies a glucocorticoid induced model was used, while in 12 of the studies an ovariectomised model was used, and for the other six studies an orchidectomised model was used as the osteoporotic model. All of the studies reported varied results based on the type of herbs used, but in comparison to Eurycoma longifolia, Piper sarmentosum and Labisia pumila recorded better anti-osteoporotic effects, while the majority of studies on Eurycoma longifolia were unable to preserve bone strength. - Some of the metrics are blocked by yourconsent settings
Publication A micro-computed tomography (micro-CT) analysis of postmenopausal osteoporotic rat models supplemented with ficus carica(Open Science Publishers LLP Inc., 2018) ;Mohammad A. ;Razaly N.I. ;Rani M.D.M. ;Muhammad Shamsir Mohd Aris ;Dom S.M. ;Effendy N.M. ;Faculty of Medicine and Health Sciences ;Universiti Sains Islam Malaysia (USIM)Universiti Teknologi MARA (UiTM)Estrogen replacement therapy (ERT) is known to be effective as an anti-osteoporotic treatment for postmenopausal women but exerted many adverse effects. Ficus carica (FC) or fig is a fruit rich in antioxidants and anti-inflammatory sources that are believed to contribute to its potential as ERT alternative. This study aimed to evaluate the effects of FC supplementation on the trabecular microarchitecture of postmenopausal osteoporotic rat models. Fifty-six adult female Sprague-Dawley rats were randomly divided into groups of Sham-operated (Sham), ovariectomized control (OVX), ovariectomized with 64.5 ?g/kg estrogen Premarin (ERT), ovariectomized with 50 mg/kg aqueous extract of FC (FC50), ovariectomized with 100 mg/kg aqueous extract of FC (FC100), ovariectomized with 50 mg/kg raw extract of FC (RAW50) and ovariectomized with 100 mg/kg raw extract of FC (RAW100). The treatments were given daily via oral gavage for eight weeks. After the treatment, rats were euthanized and femora were dissected out for micro-computed tomography (micro-CT) analysis. Trabecular structure of OVX femur showed significant osteoporotic deterioration in bone volume, trabecular separation, structural model index and connectivity density. ERT significantly reversed the osteoporotic-induced bone changes comparable to Sham level. RAW50 showed the best FC treatment in preserving bone microarchitecture. In conclusion, raw extraction of FC has high potential as an alternative against osteoporosis due to its high mineral contents and bioactive compounds.