The aim of this systematic review is to determine the effectiveness of arthroscopic lysis and lavage as a diagnostic and therapeutic tool for management of internal derangement of temporomandibular joint. Method: A systematic review will be conducted according to the guidance of Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Search strategy will be tailored according to Population, Intervention, Comparison, Outcome and Study design (PICOS) approach. Ovid Medline, CINAHL Complete, ScienceDirect, Web of Science, Cochrane centre register for clinical trials and Pub-med data bases will be searched from1975 to 2020. Truncation, Boolean and Proximity operators will be applied as appropriate. Cochrane’s tool for risk of bias assessment will be used for randomised trials and for non-randomised studies, Newcastle Ottawa Scale will be used. Narrative synthesis will be conducted for all the included studies and if an adequate data were available, a meta-analysis will be conducted. Significance: The study will systematically assess the therapeutic potential of arthroscopic lysis and lavage and define its position in the ladder of management of internal derangement of temporomandibular joint in comparison to other lines of treatment. It will also investigate the diagnostic limit of temporomandibular joint arthroscopy in assessment of disc status and its ability to detect adhesions and perforations in comparison to magnetic resonance imaging. Keywords: Temporomandibular Joint, Arthroscopy, Magnetic Resonance Imaging.