Dengue is a public health concern with an economic burden that is currently unmet by approved vaccinations, particular treatment medicines, or effective vector-control methods. It can be challenging to identify in an early stage, and if not treated properly, it can have disastrous effects. We, therefore, present a case of an unfortunate man diagnosed with severe dengue. He eventually had a multiorgan failure and required renal replacement therapy and inotropic support. We emphasize early recognition and investigation of dengue fever to prevent such serious complications later. We also discuss the clinical condition with radiological intervention such as assessing gallbladder wall thickness as a tool when in doubt of a diagnosis of severe dengue infection.