Browsing by Author "Samat, NA"
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Publication Antimicrobial susceptibility of clinical isolates of Pseudomonas aeruginosa from a Malaysian Hospital(Univ Sains Malaysia, Sch Medical Sciences, 2009) ;Pathmanathan, SG ;Samat, NAMohamed, ROngoing surveillance of Pseudomonas aeruginosa resistance against antimicrobial agents is fundamental to monitor trends in susceptibility patterns and to appropriately guide clinicians in choosing empirical or directed therapy. The in vitro activity level of eight antimicrobial drugs was assessed against 97 clinical isolates of P. aeruginosa collected consecutively for three months in 2007 from a Malaysian hospital. Antimicrobial susceptibility was determined using the E-test method in addition to the hospital's routine diagnostic testing by the disk diffusion method. Respiratory and wound swab isolates were the most frequently encountered isolates. The E-test and disk diffusion methods showed high concordance in determining the in vitro activity of the antimicrobial agents against the E isolates. Piperacillin-tazobactam was the most active antimicrobial agent with 91.8% susceptibility, followed by the aminoglycosides (amikacin, 86.6% and gentamicin, 84.5%), the quinolone (ciprofloxacin, 83.5%) and the beta-lactams (cefepime, 80.4%, ceftazidime, 80.4%, imipenem, 79.4% and meropenem, 77.3%). Incidence of multidrug resistance was 19.6% (19 out of 97 isolates). Periodic antibiotic resistance surveillance is fundamental to monitor changes in susceptibility patterns in a hospital setting. - Some of the metrics are blocked by yourconsent settings
Publication Pseudomonas aeruginosa: Antimicrobial Susceptibility Testing and Agreement Between Disk Diffusion and E-Test Methods(Elsevier Sci Ltd, 2008) ;Pathmanathan, SG ;Samat, NAMohamed, RBackground: The intrinsic resistance of Pseudomonas aeruginosa towards several antimicrobial agents has contributed to its role as an effective opportunistic pathogen and its emergence as one of the most problematic human pathogens. The aim of this study was to assess the susceptibility patterns of eight commonly used antimicrobial agents against clinical isolates of Pseudomonas aeruginosa. Methods: A total of 97 Pseudomonas aeruginosa strains were isolated from various clinical specimens at the Kuala Lumpur Hospital, Malaysia between October and December 2007. Antimicrobial susceptibility was determined using the E-test method subsequent to the hospital's routine diagnostic testing by the disk diffusion (DD) method. Results were interpreted according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: Total agreement of DD and E-test methods was 99% for susceptibility to gentamicin, ciprofloxacin and ceftazidime, 98% for susceptibility to amikacin, piperacillin/tazobactam, imipenem and meropenem and 97% for susceptibility to cefepime. According to the E-test method, the rates of susceptible isolates were piperacillin/tazobactam 91%, amikacin 87%, gentamicin 85%, ciprofloxacin 84%, ceftazidime and cefepime 80% each, imipenem 79% and meropenem 77%. 24% of the isolates were resistant to two or more antimicrobial agents.