The home remedy of taking honey along with a citrus juice of lemon, lime or calamansi to soothe sore throat has long been practiced in many cultures across the world since ancient times. This paper aims to systematically review the antibacterial effect of honey and citrus juice on Streptococcus pyogenes by means of a systematic search in EBSCOhost, Medline, Scopus and ISI Web of Science databases for reports of studies investigating the antibacterial effects of honey and citrus fruit juice on S. pyogenes. A total of 415 publications were initially identified out of which, 20 were finally chosen and reviewed by looking at the tittles, abstracts and fullpaper usingpre-determined inclusion and exclusion criteria in relation to honey (n=16) and citrus (n=4). The majority of the studies showed that both honey and citrus have significant antimicrobial effect on S. pyogenes. There are still not many available data though on the combined effect of honey and citrus on the bacterium. This knowledge gap offers an opportunity to investigate those effects with the purpose of supporting traditional practice with scientific evidences.

Neuropathy is a problem often suffered by patients with diabetes mellitus. Types of neuropathy that occur are peripheral neuropathy and autonomic neuropathy. This cross sectional study was conducted to determine the association between duration of diabetes and loss of protective sensation and the association between imbalance and loss of protective sensation among Malay women with diabetes mellitus. Eighty one Malay women. with diabetes mellitus, aged 20 to 60 years from three clinics in Hulu Langat District participated in this study. Socio-demographic information were obtained from respondent using a questionnaire. Foot sensory evaluation was conducted using Semmes-Weinstein Monofilament grade 5.07. Assessment of balance was done using Timed One-leg Stance. Chi-squared test was used to determine the association between the two variables. Result showed that 56.8% of respondent had loss of protective sensation on at least one foot. While, 17.3% had imbalance while eyes were open and 60.5% experienced imbalance while eyes were closed. However, there was no significant correlation (p<0.05) between imbalance while eyes opened [chi(2)=3.27, p=0.07] and while eyes close [chi(2)=0.29, p=0.59]) with loss of protective sensation in at least one foot. Similar result were obtained between duration of diabetes and the loss of protective sensation. (chi(2) =3.27, p=0.20). Although there was no association between these factors, a screening program should start early to ensure early problems are identified before more severe complications occur.