Browsing by Author "Saxena, AK"
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Publication Anti-atherosclerotic Effects of Eurycoma Longifolia (Tongkat Ali) in Rats Fed on High-fat Diet(Int Islamic Univ Malaysia, Kulliyyah Medicine, 2017) ;Al-Joufi, F ;Saxena, AK ;Al-Ani, IM ;Talib, NA ;Mokhtar, RHKu-Zaifah, NAtherosclerosis in cardiovascular disease (CVD) is a growing health problem, especially in developing countries. Hyperlipidemia is known as a dominant risk factor for the development of atherosclerosis. This study was designed to investigate the effects of Eurycoma Longifolia (EL) also known as Malaysian Ginseng/Tongkat Ali on the testosterone level, biochemical changes of lipid profile and intima media thickness (IMT) in rats fed on high-fat diet. Twenty young, adult male Sprague-Dawley (SD) rats were housed for 12 weeks. After one week of acclimatization, they were randomly divided into four groups of 5 animals each and treated for 12 weeks as follow: Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15mg/kg) dissolved in distilled water, group HFD was given only high fat diet and group HFDEL was given high fat diet and EL extracts (15mg/kg). Rats which were treated with EL (NDEL and HFDEL) showed a significant increase (p<0.05) in the testosterone levels. There was a significant decrease (p<0.05) in triglyceride (TG) in HFDEL group compered to HFD group. The histological sections of aortas revealed a significant decrease (p<0.05) in IMT in HFDEL as compared with HFD group. No histological changes were observed in NDEL group compared with ND group and there was no significant difference in IMT values between NDEL and ND. These findings suggest that EL is a promising protective agent against atherosclerosis induced by high-fat diet. - Some of the metrics are blocked by yourconsent settings
Publication Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study(Sociedad Anatomica Espanola, 2016) ;Al-Joufi, F ;Al-Ani, IM ;Saxena, AK ;Talib, NA ;Mokhtar, RH ;Ku-Zaifah, N ;Faculty of Medicine and Health Sciences ;International Islamic University Malaysia (IIUM)Universiti Sains Islam Malaysia (USIM)The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group ND was given only normal diet, Group NDEL was given normal diet and EL, Group HFD was given only high fat diet, Group HFDEL was given HFD and EL extracts. The aortic thicknesses of the intima media were photographed and measured with Dino-Capture (R) 2.0. In this study, the HFD produced obvious atherosclerotic plaque; treatment with aqueous extract of EL has reduced the size and formation of atherosclerotic plaque. The aortic IMT was more significantly increased in the HFD group than that of ND (p < 0.05); on the other hand, the aortic IMT was more significantly reduced in HFDEL group than that of HFD group (p < 0.05). It is concluded that the aqueous extract of EL significantly attenuated the formation of atherosclerotic plaques in the aorta of rats and preserved the vascular structure.