The brain is the main organ that processes a lot of information, including emotion and cognitive behaviour. This paper aims to highlight the dynamic reorganization of the brain connectivity model associated with pain, love, and empathy responses. Various approaches in cognitive neuroscience use functional neuroimaging methods to determine the brain activation areas via visual stimulus, emotion label inventories, face recognition, and physical pain stimulation. The brain activation areas were recognized according to the types of tasks chosen for the participants, such as emotional expression, face detection, and physical pain-induced tasks. These three emotional categories have their respective neural correlation and share some activation areas that comprise empathy-pain and love-pain related. This area of research has brought many benefits in the healthcare sector in which physicians and psychologists, as well as other people, understand and explore more about their body functions, thus leading them to foster healthier relationships and emotional awareness.