Browsing by Author "Sulaiman W.S.W."
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Publication Effects of goat milk and its products on human pathogenic bacteria: A systematic review(American Scientific Publishers, 2017) ;Zamri N.A. ;Ishak N.F.M. ;Abdullah N. ;Sulaiman W.S.W. ;Faculty of Medicine and Health SciencesUniversiti Sains Islam Malaysia (USIM)Goat milk has been consumed widely due to its various benefits to health. It was part of the prophetic diet during the times of the Prophet Muhammad, his family and companions. It has been shown to exhibit antimicrobial activities to various pathogens which are attributed to the presence of bioactive peptides, lactoperoxidase and immunoglobulins. This systematic review aims to assess the evidence of antibacterial effects of goat milk and its products on human pathogenic bacteria. We performed a systematic literature search of Scopus, EMBASE, Medline and PubMed until August 2016. In addition, we used Google Scholar and screened the references for additional studies. We included experimental studies which tested the antibacterial activities of goat milk and its products. Only studies on human pathogenic bacteria were included. Data were collected on the substance tested, methods used as well as the antibacterial effects observed. Risks of biases associated with the studies were also assessed. We identified 10 studies that met the inclusion criteria. These included antibacterial activities of goat milk, whey, goat cheese, yogurt and colostrum. All of the studies showed significant inhibition against various gram-positive and gram-negative human pathogenic bacteria especially E. coli. The antibacterial effect was significantly higher when the protein was hydrolysed using human or animal proteolytic enzyme. The antibacterial effects were mainly attributed to the presence of various types of peptides such as lactoferrin. In addition, a study also exhibited antibacterial activity of the enzyme lactoperoxidase. This systematic review has shown significant antibacterial effects of goat milk and its products such as whey, goat cheese, yogurt and colostrum against human pathogenic bacteria. The activities differ according to the types of bacterial strain and peptides as well as hydrolysation of the milk protein. � 2017 American Scientific Publishers All rights reserved. - Some of the metrics are blocked by yourconsent settings
Publication Staphylococcus aureus carriage in selected kindergartens in Klang Valley(Malaysian Medical Association, 2016) ;Mohamed N.A. ;Ramli S. ;Amin N.N.Z. ;Sulaiman W.S.W. ;Isahak I. ;Jamaluddin T.Z.M.T. ;Salleh N.M. ;Faculty of Medicine and Health Sciences ;Universiti Sains Islam Malaysia (USIM)Universiti Putra Malaysia (UPM)Introduction: Nasal colonisation of S. aureus in healthy children was 18% to 30%. One to three percent of them were colonised by Methicillin-resistant Staphlycoccus aureus (MRSA). Although MRSA infection has become increasingly reported, population-based S. aureus and MRSA colonisation estimates are lacking. The main objective of this study was to determine the prevalence of S. aureus carriage among children. Methods: Nasal samples for S. aureus culture were obtained from 250 children from three kindergartens in the Klang Valley, after consent was obtained from the children and their parents. Swabs were transported in Stuart medium, and inoculated on mannitol-salt agar within four hours of collection. Identification and disk diffusion test were done according to guidelines. Polymerase chain reaction was done on MRSA isolates for the presence of mecA and lukS/FPV genes. Results: Overall prevalence of S. aureus and MRSA carriage were 19.2% (48/250) and 1.6% (4/250) respectively. mecA gene was present in all isolates, 50% isolates carried Panton-Valentine leucocidin (PVL) gene. Sccmec type I was found in 2 isolates and the remaining isolates has Sccmec type V. Conclusion: The prevalence of S. aureus and MRSA carriage were similar to other studies. However, risk of contracting severe infection might be higher due to presence of PVL gene in half of the MRSA isolates. � 2016, Malaysian Medical Association. All rights reserved.