Browsing by Author "Yacine Hadjiat"
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Publication In vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2: implications for dental practice(Universiti Sains Islam Malaysia, 2020-12) ;Pouya Hassandarvish ;Vunjia Tiong ;Nurul Azmawati Mohamed ;Harsha Arumugam ;Abhishek Ananthanarayanan ;Murtaza Qasuri ;Yacine HadjiatSazaly AbubakarINTRODUCTION Virus particles in respiratory droplets and aerosols generated during medical/dental procedures are a potential source of SARS-CoV-2 cross infection. In the dental setting, oral decontamination could be an important adjunct to personal protective equipment and is recommended by a number of national COVID-19 guidance documents for dental settings. AIM To assess the in vitro virucidal activity of an oral povidone iodine (PVP-I) product against SARS-CoV-2. MATERIAL AND METHODS BETADINE gargle and mouthwash (1% PVP-I) was tested against SARS-CoV-2 virus under both clean and dirty conditions using a suspension assay based on EN14476 methodology. Virucidal activity of the product, undiluted and at 1:2 dilution, was tested at contact times of 15, 30 and 60 seconds. Viral titres were calculated using the Spearman-Kärber method and reported as median tissue culture infectious dose (TCID50/ml). RESULTS The undiluted product achieved >5 log10 reduction in viral titres compared to the control at 15, 30 and 60 seconds under both clean and dirty conditions. At a twofold dilution (0.5% PVP-I), the test product demonstrated >4 log10 kill at 15 seconds and >5 log10 kill at 30 and 60 seconds in both clean and dirty conditions. CONCLUSION PVP-I gargle and mouthwash product, undiluted and at 1:2 dilution, demonstrated potent and rapid virucidal activity (≥4 log10 reduction of viral titre) in 15 seconds against SARS-CoV-2 in vitro. The PVP-I gargle and mouthwash product is widely available and could be readily integrated into infection control measures during dental treatment including pre-procedural oral decontamination.