Goat milk has been consumed widely due to its various benefits to health. It was part of the prophetic diet during the times of the Prophet Muhammad, his family and companions. It has been shown to exhibit antimicrobial activities to various pathogens which are attributed to the presence of bioactive peptides, lactoperoxidase and immunoglobulins. This systematic review aims to assess the evidence of antibacterial effects of goat milk and its products on human pathogenic bacteria. We performed a systematic literature search of Scopus, EMBASE, Medline and PubMed until August 2016. In addition, we used Google Scholar and screened the references for additional studies. We included experimental studies which tested the antibacterial activities of goat milk and its products. Only studies on human pathogenic bacteria were included. Data were collected on the substance tested, methods used as well as the antibacterial effects observed. Risks of biases associated with the studies were also assessed. We identified 10 studies that met the inclusion criteria. These included antibacterial activities of goat milk, whey, goat cheese, yogurt and colostrum. All of the studies showed significant inhibition against various gram-positive and gram-negative human pathogenic bacteria especially E. coli. The antibacterial effect was significantly higher when the protein was hydrolysed using human or animal proteolytic enzyme. The antibacterial effects were mainly attributed to the presence of various types of peptides such as lactoferrin. In addition, a study also exhibited antibacterial activity of the enzyme lactoperoxidase. This systematic review has shown significant antibacterial effects of goat milk and its products such as whey, goat cheese, yogurt and colostrum against human pathogenic bacteria. The activities differ according to the types of bacterial strain and peptides as well as hydrolysation of the milk protein. � 2017 American Scientific Publishers All rights reserved.