This research aimed to review the fatwa imposed by Malaysian National Fatwa Council (MNFC) upon porcine base Low Molecular Weight Heparin (LMWH) anticoagulant specifically Enoxaparin Sodium for thromboprophylaxis (prevention) and therapeutic treatment. This research employs qualitative methodology through documents analysis and interviews with which 17 expertise in various field. Nine medical specialists from three departments; six of them were from the obstetrics and gynecology (O&G) department, followed by a hematologist a cardiovascular physician and a family medicine specialist. Two senior’s pharmaceutical expert and six shariah scholars which were the experts from various Public Universities around Malaysia interviewees panel in this research. The outcome from the expert consensus revealed that Venous Thromboembolism (VTE) is ensured as a fatal and life-threatening illness particularly during pregnancy and puerperium and applicable to use Clexane as prevention and therapy. Albeit it has porcine intestinal mucosa origin which has been depolymerized in preparation, the usage of enoxaparin sodium like Clexane as LMWH anticoagulant in pregnancy and puerperium is needed based on pivotal factors such as accessibility, feasibility, effective and safety profile. The efficacy and effectiveness of enoxaparin sodium like Clexane as LMWH anticoagulant as prevention (prophylaxis) before developing any VTE complications in high risk cases and treatment are concurred by the expert clinicians and therefore based on the justification of Islamic legal maxims namely al-darar yuzal and al-hajah tunazzal manzilah al-darurah.