Publication: In vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2: implications for dental practice
dc.contributor.author | Pouya Hassandarvish | en_US |
dc.contributor.author | Vunjia Tiong | en_US |
dc.contributor.author | Nurul Azmawati Mohamed | en_US |
dc.contributor.author | Harsha Arumugam | en_US |
dc.contributor.author | Abhishek Ananthanarayanan | en_US |
dc.contributor.author | Murtaza Qasuri | en_US |
dc.contributor.author | Yacine Hadjiat | en_US |
dc.contributor.author | Sazaly Abubakar | en_US |
dc.date.accessioned | 2024-05-27T15:03:34Z | |
dc.date.available | 2024-05-27T15:03:34Z | |
dc.date.issued | 2020-12 | |
dc.date.submitted | 2021-2-9 | |
dc.description | BRITISH DENTAL JOURNAL | ONLINE PUBLICATION | DECEMBER 10 2020 | en_US |
dc.description.abstract | INTRODUCTION Virus particles in respiratory droplets and aerosols generated during medical/dental procedures are a potential source of SARS-CoV-2 cross infection. In the dental setting, oral decontamination could be an important adjunct to personal protective equipment and is recommended by a number of national COVID-19 guidance documents for dental settings. AIM To assess the in vitro virucidal activity of an oral povidone iodine (PVP-I) product against SARS-CoV-2. MATERIAL AND METHODS BETADINE gargle and mouthwash (1% PVP-I) was tested against SARS-CoV-2 virus under both clean and dirty conditions using a suspension assay based on EN14476 methodology. Virucidal activity of the product, undiluted and at 1:2 dilution, was tested at contact times of 15, 30 and 60 seconds. Viral titres were calculated using the Spearman-Kärber method and reported as median tissue culture infectious dose (TCID50/ml). RESULTS The undiluted product achieved >5 log10 reduction in viral titres compared to the control at 15, 30 and 60 seconds under both clean and dirty conditions. At a twofold dilution (0.5% PVP-I), the test product demonstrated >4 log10 kill at 15 seconds and >5 log10 kill at 30 and 60 seconds in both clean and dirty conditions. CONCLUSION PVP-I gargle and mouthwash product, undiluted and at 1:2 dilution, demonstrated potent and rapid virucidal activity (≥4 log10 reduction of viral titre) in 15 seconds against SARS-CoV-2 in vitro. The PVP-I gargle and mouthwash product is widely available and could be readily integrated into infection control measures during dental treatment including pre-procedural oral decontamination. | en_US |
dc.identifier.citation | Hassandarvish, P., Tiong, V., Mohamed, N. et al. In vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2: implications for dental practice. Br Dent J (2020). https://doi.org/10.1038/s41415-020-2402-0 | en_US |
dc.identifier.doi | 10.1038/s41415-020-2402-0 | |
dc.identifier.epage | 4 | |
dc.identifier.issn | 0007-0610 | |
dc.identifier.issue | 10 | |
dc.identifier.other | 900-40 | |
dc.identifier.spage | 1 | |
dc.identifier.uri | https://oarep.usim.edu.my/handle/123456789/4103 | |
dc.identifier.volume | - | |
dc.language.iso | en | en_US |
dc.publisher | Universiti Sains Islam Malaysia | en_US |
dc.relation.ispartof | British Dental Journal (BDJ) | en_US |
dc.title | In vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2: implications for dental practice | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication |
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