Publication:
In vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2: implications for dental practice

Simple item page
dc.contributor.authorPouya Hassandarvishen_US
dc.contributor.authorVunjia Tiongen_US
dc.contributor.authorNurul Azmawati Mohameden_US
dc.contributor.authorHarsha Arumugamen_US
dc.contributor.authorAbhishek Ananthanarayananen_US
dc.contributor.authorMurtaza Qasurien_US
dc.contributor.authorYacine Hadjiaten_US
dc.contributor.authorSazaly Abubakaren_US
dc.date.accessioned2024-05-27T15:03:34Z
dc.date.available2024-05-27T15:03:34Z
dc.date.issued2020-12
dc.date.submitted2021-2-9
dc.descriptionBRITISH DENTAL JOURNAL | ONLINE PUBLICATION | DECEMBER 10 2020en_US
dc.description.abstractINTRODUCTION Virus particles in respiratory droplets and aerosols generated during medical/dental procedures are a potential source of SARS-CoV-2 cross infection. In the dental setting, oral decontamination could be an important adjunct to personal protective equipment and is recommended by a number of national COVID-19 guidance documents for dental settings. AIM To assess the in vitro virucidal activity of an oral povidone iodine (PVP-I) product against SARS-CoV-2. MATERIAL AND METHODS BETADINE gargle and mouthwash (1% PVP-I) was tested against SARS-CoV-2 virus under both clean and dirty conditions using a suspension assay based on EN14476 methodology. Virucidal activity of the product, undiluted and at 1:2 dilution, was tested at contact times of 15, 30 and 60 seconds. Viral titres were calculated using the Spearman-Kärber method and reported as median tissue culture infectious dose (TCID50/ml). RESULTS The undiluted product achieved >5 log10 reduction in viral titres compared to the control at 15, 30 and 60 seconds under both clean and dirty conditions. At a twofold dilution (0.5% PVP-I), the test product demonstrated >4 log10 kill at 15 seconds and >5 log10 kill at 30 and 60 seconds in both clean and dirty conditions. CONCLUSION PVP-I gargle and mouthwash product, undiluted and at 1:2 dilution, demonstrated potent and rapid virucidal activity (≥4 log10 reduction of viral titre) in 15 seconds against SARS-CoV-2 in vitro. The PVP-I gargle and mouthwash product is widely available and could be readily integrated into infection control measures during dental treatment including pre-procedural oral decontamination.en_US
dc.identifier.citationHassandarvish, P., Tiong, V., Mohamed, N. et al. In vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2: implications for dental practice. Br Dent J (2020). https://doi.org/10.1038/s41415-020-2402-0en_US
dc.identifier.doi10.1038/s41415-020-2402-0
dc.identifier.epage4
dc.identifier.issn0007-0610
dc.identifier.issue10
dc.identifier.other900-40
dc.identifier.spage1
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/4103
dc.identifier.volume-
dc.language.isoenen_US
dc.publisherUniversiti Sains Islam Malaysiaen_US
dc.relation.ispartofBritish Dental Journal (BDJ)en_US
dc.titleIn vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2: implications for dental practiceen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
In vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2; implications for dental practice.pdf
Size:
308.85 KB
Format:
Adobe Portable Document Format
Description:
In vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2: implications for dental practice
Download

Collections

Other Publications