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Association Of Micro RNA And Postoperative Cognitive Dysfunction: A Review

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dc.contributor.authorYazit N.A.A.en_US
dc.contributor.authorJuliana N.en_US
dc.contributor.authorDas S.en_US
dc.contributor.authorTeng N.I.M.F.en_US
dc.contributor.authorFahmy N.M.en_US
dc.contributor.authorAzmani S.en_US
dc.contributor.authorKadiman S.en_US
dc.date.accessioned2024-05-29T02:09:07Z
dc.date.available2024-05-29T02:09:07Z
dc.date.issued2020
dc.descriptionMini-Reviews in Medicinal Chemistry Volume 20 , Issue 17 , 2020en_US
dc.description.abstractPostoperative Cognitive Dysfunction (POCD) refers to the condition of neurocognitive decline following surgery in a cognitive and sensory manner. There are several risk factors, which may be life-threatening for this condition. Neuropsychological assessment of this condition is very im-portant. In the present review, we discuss the association of apolipoprotein epsilon 4 (APOE ?4) and few miRNAs with POCD, and highlight the clinical importance for prognosis, diagnosis and treatment of POCD. Microarray is a genome analysis that can be used to determine DNA abnormalities. This current technique is rapid, efficient and high-throughout. Microarray techniques are widely used to di-agnose diseases, particularly in genetic disorder, chromosomal abnormalities, mutations, infectious diseases and disease-relevant biomarkers. MicroRNAs (miRNAs) are a class of non-coding RNAs that are widely found distributed in eukaryotes. Few miRNAs influence the nervous system development, and nerve damage repair. Microarray approach can be utilized to understand the miRNAs involved and their pathways in POCD development, unleashing their potential to be considered as a diagnostic marker for POCD. This paper summarizes and identifies the studies that use microarray based approaches for POCD analysis. Since the application of microarray in POCD is expanding, there is a need to review the current knowledge of this approach. 2020 Bentham Science Publishers.en_US
dc.identifier.citationNoor Anisah Abu Yazit, Norsham Juliana*, Srijit Das, Nur Islami Mohd Fahmi Teng, Nadia Mohd Fahmy, Sahar Azmani and Suhaini Kadiman, “Association of Micro RNA and Postoperative Cognitive Dysfunction: A Review”, Mini-Reviews in Medicinal Chemistry 2020; 20(17) . https://doi.org/10.2174/1389557520666200621182717en_US
dc.identifier.doihttps://doi.org/10.2174/1389557520666200621182717
dc.identifier.epage1790
dc.identifier.issn13895575
dc.identifier.issue17
dc.identifier.scopus2-s2.0-85091919257
dc.identifier.spage1781
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85091919257&doi=10.2174%2f1389557520666200621182717&partnerID=40&md5=da88a60f723bcff51ea5750c66eca6cf
dc.identifier.urihttps://www.eurekaselect.com/183005/article
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10452
dc.identifier.volume20
dc.languageEnglish
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.relation.ispartofMini-Reviews in Medicinal Chemistryen_US
dc.sourceScopus
dc.subjectCognitiveen_US
dc.subjectFunctionen_US
dc.subjectMicroarrayen_US
dc.subjectmiRNAen_US
dc.subjectPOCDen_US
dc.subjectTreatmenten_US
dc.titleAssociation Of Micro RNA And Postoperative Cognitive Dysfunction: A Reviewen_US
dc.typeArticleen_US
dspace.entity.typePublication

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