Publication:
Chronic photoperiod disruption does not increase vulnerability to focal cerebral ischemia in young normotensive rats

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dc.contributor.authorKu Mastura Ku Mohd Nooren_US
dc.contributor.authorCathy Wyseen_US
dc.contributor.authorLisa A Royen_US
dc.contributor.authorStephany M Bielloen_US
dc.contributor.authorChristopher McCabeen_US
dc.contributor.authorDeborah Dewaren_US
dc.date.accessioned2024-05-28T05:48:41Z
dc.date.available2024-05-28T05:48:41Z
dc.date.issued2017
dc.descriptionVolume: 37 Issue: 11en_US
dc.description.abstractPhotoperiod disruption, which occurs during shift work, is associated with changes in metabolism or physiology (e.g. hypertension and hyperglycaemia) that have the potential to adversely affect stroke outcome. We sought to investigate if photoperiod disruption affects vulnerability to stroke by determining the impact of photoperiod disruption on infarct size following permanent middle cerebral artery occlusion. Adult male Wistar rats (210-290 g) were housed singly under two different light/dark cycle conditions (n=12 each). Controls were maintained on a standard 12:12 light/dark cycle for nine weeks. For rats exposed to photoperiod disruption, every three days for nine weeks, the lights were switched on 6 h earlier than in the previous photoperiod. T2-weighted magnetic resonance imaging was performed at 48 h after middle cerebral artery occlusion. Disruption of photoperiod in young healthy rats for nine weeks did not alter key physiological variables that can impact on ischaemic damage, e.g. blood pressure and blood glucose immediately prior to middle cerebral artery occlusion. There was no effect of photoperiod disruption on infarct size after middle cerebral artery occlusion. We conclude that any potentially adverse effect of photoperiod disruption on stroke outcome may require additional factors such as high fat/high sugar diet or pre-existing co-morbidities.en_US
dc.identifier.doi10.1177/0271678X16671316
dc.identifier.epage3588
dc.identifier.issn0271-678X
dc.identifier.issue11
dc.identifier.spage3580
dc.identifier.urihttps://journals.sagepub.com/doi/pdf/10.1177/0271678X16671316
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/6569
dc.identifier.volume37
dc.language.isoen_USen_US
dc.publisherSAGE Publicationsen_US
dc.relation.ispartofJournal of Cerebral Blood Flow and Metabolismen_US
dc.subjectAnimal model, focal ischemia, circadian rhythm, hyperglycaemia, photoperiod disruptionen_US
dc.titleChronic photoperiod disruption does not increase vulnerability to focal cerebral ischemia in young normotensive ratsen_US
dc.typeAnimationen_US
dspace.entity.typePublication

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