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The effects of Ficus carica fruit on bone markers and oestrogen level of post-menopausal osteoporotic rats

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dc.FundingDetailsMinistry of Higher Education, Malaysia: USIM/FRGS/FPSK/32/50216
dc.FundingDetailsWe would like to thank Ministry of higher Education for funding this study (USIM/FRGS/FPSK/32/50216). We also like to thank to Faculty of Medicine and Health Sciences of Universiti Sains Islam Malaysia (USIM) and all the staffs involve in this study.
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorNorfarah Izzaty R.en_US
dc.contributor.authorNur Adlina M.en_US
dc.contributor.authorMohd Dzulkhairi M.R.en_US
dc.contributor.authorMuhammad Shamsir M.A.en_US
dc.contributor.authorNadia M.E.en_US
dc.date.accessioned2024-05-28T08:39:05Z
dc.date.available2024-05-28T08:39:05Z
dc.date.issued2019
dc.description.abstractIntroduction: Post-menopausal osteoporosis is the most common type of osteoporosis, which occurs due to a deficiency of oestrogen following menopause. Considering the adverse effects of oestrogen replacement therapy, natural products may serve to replace the current conventional treatment. Ficus carica (FC) which is commonly known as fig may have a potential in treating post-menopausal osteoporosis due to their abundance of important minerals and bioactive compounds such as phenolic, flavonoid and anthocyanins. This study aimed to evaluate the effects of FC on bone metabolism of ovariectomized rats. Materials and Methods: Fifty-six female Spraque-Dawley rats were randomly divided into seven groups; SHAM operated (SHAM), ovariectomized control (OVX), ovariectomized + 64.5 ?g/kg oestrogen (ERT), ovariectomized + 50 mg/kg aqueous extract of FC (AQ50), ovariectomized + 100 mg/kg aqueous extract of FC (AQ100), ovariectomized + 50 mg/kg raw FC (RW50), and ovariectomized + 100 mg/kg raw FC (RW100). After eight weeks of treatments, rats were euthanized and femurs were dissected out to measure bone osteocalcin, Ctelopeptide of type 1 collagen and bone estrogen level. Results: RW50 and RW100 showed an increasing trend in osteocalcin levels and also oestrogen level, but no significant difference between all groups. RW50 and RW100 also showed significantly reduced C-telopeptide of type 1 collagen levels compared to OVX group. Conclusion: These findings suggested that raw FC at the doses of 50 mg/kg and 100 mg/kg have potential to improve bone in treating post-menopausal osteoporosis. However, this need to be confirmed with higher doses. � 2019 Default.
dc.description.natureFinalen_US
dc.identifier.epage104
dc.identifier.issn18234631
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85065566217
dc.identifier.spage97
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85065566217&partnerID=40&md5=170f7201e84f9f3d27902b7e8219e911
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9232
dc.identifier.volume18
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherInternational Islamic University Malaysiaen_US
dc.relation.ispartofInternational Medical Journal Malaysia
dc.sourceScopus
dc.subjectBone markeren_US
dc.subjectCTX-1en_US
dc.subjectFicus caricaen_US
dc.subjectOsteocalcinen_US
dc.subjectPost-menopausal osteoporosisen_US
dc.titleThe effects of Ficus carica fruit on bone markers and oestrogen level of post-menopausal osteoporotic ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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