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Preliminary study on the synthesis of kojic acid monooleate using dual enzymes system

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dc.Conferencecode141987
dc.Conferencedate29 April 2018 through 30 April 2018
dc.Conferencename4th International Conference on Green Design and Manufacture 2018, IConGDM 2018
dc.contributor.affiliationsFaculty of Science and Technology
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorRadzi S.M.en_US
dc.contributor.authorZulhilmi M.N.M.en_US
dc.contributor.authorNoor H.M.en_US
dc.contributor.authorRehan M.M.en_US
dc.date.accessioned2024-05-28T08:42:28Z
dc.date.available2024-05-28T08:42:28Z
dc.date.issued2018
dc.description.abstractKojic acid is an organic acid that widely used in cosmetic, health care, food and chemical industries. However, kojic acid is not stable at high temperature, for long storage and it has low lipophilic properties. To overcome this problem, a study was conducted to improve its properties by enzymatic reaction. This study was focused on the synthesis of kojic acid monooleate from kojic acid and oleic acid using enzymatic catalysts at optimized conditions. This study was divided into three parts starting from enzymatic synthesis of kojic ester or specifically kojic acid monooleate (KAMO) by using a dual enzymes system that consisted of Novozym 435 and Lipozyme RM IM. Then, optimization of four variables such as screening of dual enzymes ratio, temperature, substrate molar ratio and the reaction time via conventional method of one parameter at-a-time approach and lastly verification of the product using Fourier Transfer Infrared (FTIR) spectroscopy. The optimum conditions for the enzymatic synthesis of KAMO were at the dual enzymes ratio (1:1) of Novozym 435 and Lipozyme RMIM, temperature at 50C, the molar ratio of kojic acid and oleic acid were 4:1 respectively and 24 hours of reaction time. The highest percentage conversion of KAMO achieved at the most optimum conditions was 13.22 %. Finally, kojic ester produced was verified by using FTIR proved the presence of ester bond (C=O) at 1743 cm-1. � 2018 Author(s).
dc.description.natureFinalen_US
dc.editorTahir M.F.B.M.Ahmad R.Saad M.N.B.M.Ghazli M.F.B.Abdullah M.M.A.-B.Rahim S.Z.B.A.Jamaludin L.B.en_US
dc.identifier.ArtNo20232
dc.identifier.doi10.1063/1.5066873
dc.identifier.isbn9780740000000
dc.identifier.issn0094243X
dc.identifier.scopus2-s2.0-85058013751
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85058013751&doi=10.1063%2f1.5066873&partnerID=40&md5=e8e9dc59d429415c2b5f12521ab49d08
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9322
dc.identifier.volume2030
dc.languageEnglish
dc.language.isoen_US
dc.publisherAmerican Institute of Physics Inc.en_US
dc.relation.ispartofAIP Conference Proceedings
dc.sourceScopus
dc.titlePreliminary study on the synthesis of kojic acid monooleate using dual enzymes system
dc.typeConference Paperen_US
dspace.entity.typePublication

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