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Synthesis and characterization of thermo- and pH-responsive bacterial cellulose/acrylic acid hydrogels for drug delivery

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dc.contributor.authorMohd Cairul Iqbal Mohd Aminen_US
dc.contributor.authorNaveed Ahmaden_US
dc.contributor.authorNadia Haliben_US
dc.contributor.authorIshak Ahmaden_US
dc.date.accessioned2024-05-27T14:36:01Z
dc.date.available2024-05-27T14:36:01Z
dc.date.issued2012
dc.date.submitted--
dc.descriptionVolume: 88 Issue; 2 (Page: 465-473)en_US
dc.description.abstractTo assist in identifying the utility of novel materials in drug-delivery applications, this study investigated the use of bacterial cellulose (BC), a natural biopolymer, in the synthesis of hydrogels for drug-delivery systems. BC was combined with different proportions of acrylic acid (AA) to fabricate hydrogels by exposure to accelerated electron-beam irradiation at different doses. Fourier transform infrared analysis revealed that the AA had been successfully grafted onto the cellulose fibers and allowed for prediction of the reaction mechanism in the synthesis of hydrogels. Thermal and morphological characterization indicated the formation of thermally stable hydrogels with pore size determined by AA content and irradiation dose. The results of swelling and in vitro drug-release studies revealed the hydrogels to be both thermo- and pH-responsive. Such thermo- and pH-responsiveness, in addition to their morphological characteristics, suggests that these BC/AA hydrogels are promising candidates as controlled drug-delivery systems.en_US
dc.identifier.doi10.1016/j.carbpol.2011.12.022
dc.identifier.epage473
dc.identifier.issn0144-8617
dc.identifier.issue2
dc.identifier.other1667-3
dc.identifier.spage465
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0144861711011374?via%3Dihub
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/3392
dc.identifier.volume88
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofCarbohydrate Polymersen_US
dc.titleSynthesis and characterization of thermo- and pH-responsive bacterial cellulose/acrylic acid hydrogels for drug deliveryen_US
dc.typeArticleen_US
dspace.entity.typePublication

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