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Preliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan

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dc.Chemicals/CASCodon; Receptors, Adrenergic, beta-2
dc.citedby4
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsInternational Islamic University Malaysia (IIUM)
dc.contributor.affiliationsPusat Kesihatan Balok
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorAtia A.E.en_US
dc.contributor.authorNorsidah K.en_US
dc.contributor.authorNor Zamzila A.en_US
dc.contributor.authorRafidah Hanim M.en_US
dc.contributor.authorSamsul D.en_US
dc.contributor.authorAznan M.A.M.en_US
dc.contributor.authorRashidah A.R.en_US
dc.contributor.authorNorlelawati A.T.en_US
dc.date.accessioned2024-05-29T02:00:13Z
dc.date.available2024-05-29T02:00:13Z
dc.date.issued2012
dc.descriptionMed J Malaysia Vol 67 No 1 February 2012en_US
dc.description.abstractPolymorphisms within the β2 -adrenergic receptor (ADRB2) gene have been repeatedly linked to hypertension. Among the ADRB2 polymorphisms detected, Arg16Gly and Gln27Glu codons are considered the two most important variations. The amino acid substitution at these codons may lead to abnormal regulation of ADRB2 activity. The aim of the present study was to assess the association between ADRB2 polymorphisms and hypertension. This case-control study consisted of 100 unrelated subjects (50 hypertensive and 50 matched normal controls). Arg16Gly and the Gln27Glu polymorphisms were analyzed by polymerase chain reactionrestriction fragment length polymorphism assay. There were no significant evidence of association in allelic and genotypes distribution of Arg16Gly and Glu27Gln with blood pressure and hypertension. These findings suggest that the variation within codon 16 and 27 of ADRB2 gene were unlikely to confer genetic susceptibility for hypertension in our population samples.en_US
dc.description.natureFinalen_US
dc.identifier.CODENMJMLA
dc.identifier.epage30
dc.identifier.issn0300-5283
dc.identifier.issue1
dc.identifier.pmid22582545
dc.identifier.scopus2-s2.0-84859402034
dc.identifier.spage25
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84859402034&partnerID=40&md5=db785f893b9e81db7cbb0781972418cc
dc.identifier.urihttp://e-mjm.org/2012/v67n1/Polymorphism.pdf
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10109
dc.identifier.volume67
dc.languageEnglish
dc.language.isoen_USen_US
dc.relation.ispartofMedical Journal of Malaysiaen_US
dc.sourceScopus
dc.subjectADRB2 geneen_US
dc.subjectBlood pressureen_US
dc.subjectHypertensionen_US
dc.subjectSingle nucleotide polymorphismen_US
dc.titlePreliminary study on association of β2 - adrenergic receptor polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantanen_US
dc.title.alternativeMed. J. Malays.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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Preliminary study on association of β2 - Adrenergic Receptor Polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan
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