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Anti-biofilm and anti-adherence activities of Spilanthes acmella leaves extracts towards Streptococcus mutans

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dc.contributor.authorRohazila Mohamad Hanafiahen_US
dc.contributor.authorSiti Sarah Azharen_US
dc.contributor.authorLuqman Atif Eliasen_US
dc.contributor.authorSiti Aisyah Abd Ghafaren_US
dc.date.accessioned2024-05-28T04:21:27Z
dc.date.available2024-05-28T04:21:27Z
dc.date.issued2018
dc.descriptionInternational Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019.en_US
dc.description.abstractBackground: Streptococcus mutans is the main causative agents of dental caries by developing biofilm and increase adherence activity. Dental caries have becoming more common due to antibiotic resistance towards Streptococcus mutans. Spilanthes acmella is well-known as anti-toothache plant with high medicinal usages. It has been recognized as an important medicinal plant with high demand worldwide. Therefore, the objective of this study is to establish antimicrobial activities, including anti-biofilm and anti-adherence activity of Spilanthes acmella on cariogenic Streptococcus mutans. Methods: Spilanthes acmella leaves extracts were prepared by serial extraction with n-hexane, dichloromethane, acetone and methanol. Antibacterial activities of these extracts were conducted using disc diffusion assay, anti-biofilm and anti-adherence activities methods. Results: The result indicates that n-hexane and methanol leaves extracts are endowed with anti-streptococcus activity. Both methanol and n-hexane extracts inhibit moderately Streptococcus mutans growth as indicated in the disc diffusion assay. Methanol and a n-hexane extracts inhibit the biofilm formation and adherence activity of Streptococcus mutans. Conclusion:This study highlights the potential of Spilanthes acmella leaves extract as a new promising anti Streptococcus mutans agents.en_US
dc.identifier.citationHanafiah R, Azhar S, Elias L and Abd Ghafar S (2019). Anti-biofilm and anti-adherence activities of Spilanthes acmella leaves extracts towards Streptococcus mutans. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00057en_US
dc.identifier.doi10.3389/conf.fphar.2018.63.00057
dc.identifier.issn1663-9812
dc.identifier.other1209-9
dc.identifier.urihttps://www.frontiersin.org/10.3389%2fconf.fphar.2018.63.00057/event_abstract
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/5325
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.relation.ispartofFrontiers Pharmacologyen_US
dc.subjectSpilanthes acmella, Streptococcus mutans, Anti-biofi lm, Anti-adherence, anti-bacteriaen_US
dc.titleAnti-biofilm and anti-adherence activities of Spilanthes acmella leaves extracts towards Streptococcus mutansen_US
dc.typeArticleen_US
dspace.entity.typePublication

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