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Prevalence And Susceptibility Of Staphylococcus Aureus Nasal Carriage Strains Isolated From Haemodialysis Patients

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dc.contributor.authorKhairunnisa Mohd Sukrien_US
dc.contributor.authorNurul Azmawati Mohameden_US
dc.contributor.authorIlina Isahaken_US
dc.contributor.authorAbdul Aziz Marwanen_US
dc.date.accessioned2024-05-29T02:27:54Z
dc.date.available2024-05-29T02:27:54Z
dc.date.issued2023
dc.date.submitted2023-5-24
dc.descriptionMJMHS VOL.19 NO. 1 Page (181-189)en_US
dc.description.abstractStaphylococcus aureus is part of the normal human flora that can commonly be found on the skin and mucous membranes of the nasal area. However, in immunosuppressed patients such as those with kidney failures, colonization can potentially lead to infection. There is a concern of increasing antibiotic resistance in S. aureus. This study aimed to determine the prevalence of S. aureus nasal colonization and its antimicrobial susceptibility among haemodialysis-dependent populations. Methods: A cross-sectional study at the Nephrology Unit, Hospital Canselori Tuanku Mukhriz (HCTM) was conducted among haemodialysis-dependent patients between February 2017 to February 2018. Nasal swabs were obtained and cultured on mannitol salt agar. S. aureus isolates were identified by gram staining, tube coagulase and Deoxyribonuclease (DNase). Cefoxitin disc (30 µg) were used to identified the presence of MRSA (methicillin-resistance S. aureus). The S. aureus colonies were further tested against six antibiotics using Kirby Bauer disc diffusion. Result: A total of 134 patients were recruited. S. aureus isolates were detected from 27 patients (20.1%). All S. aureus were phenotypically identified as methicillin-sensitive S. aureus (MSSA) based on the cefoxitin disc. Teicoplanin and linezolid were the most effective with 100% susceptibility. S. aureus exhibited a high resistance rate towards erythromycin (29.6%). No MRSA was isolated in this study. Conclusion: This study highlighted the high prevalence of S. aureus nasal colonization in haemodialysis patients. Teicoplanin and linezolid were found to be the most effective antibiotics against isolated S. aureus.en_US
dc.identifier.doi10.47836/mjmhs19.1.25
dc.identifier.epage187
dc.identifier.issn1675-8544
dc.identifier.issue1
dc.identifier.spage181
dc.identifier.urihttps://medic.upm.edu.my/upload/dokumen/2023011613291524_MJMHS_1486.pdf
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10726
dc.identifier.volume19
dc.language.isoen_USen_US
dc.publisherUPMen_US
dc.relation.ispartofMalaysian Journal of Medicine and Health Sciencesen_US
dc.subjectAntimicrobial susceptibility, Haemodialysis (HD), Methicillin-resistance Staphylococcus aureus (MRSA); Nasal carriage, Staphylococcus aureusen_US
dc.titlePrevalence And Susceptibility Of Staphylococcus Aureus Nasal Carriage Strains Isolated From Haemodialysis Patientsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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