Publication:
Anti-atherosclerotic effects of Eurycoma longifolia (tongkat ali) in rats fed on high-fat diet

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dc.contributor.authorAl-Joufi F.en_US
dc.contributor.authorSaxena A.K.en_US
dc.contributor.authorAl-Ani I.M.en_US
dc.contributor.authorTalib N.A.en_US
dc.contributor.authorMokhtar R.H.en_US
dc.contributor.authorKu-Zaifah N.en_US
dc.date.accessioned2024-05-28T08:28:08Z
dc.date.available2024-05-28T08:28:08Z
dc.date.issued2017
dc.description.abstractAtherosclerosis in cardiovascular disease (CVD) is a growing health problem, especially in developing countries. Hyperlipidemia is known as a dominant risk factor for the development of atherosclerosis. This study was designed to investigate the effects of Eurycoma Longifolia (EL) also known as Malaysian Ginseng/Tongkat Ali on the testosterone level, biochemical changes of lipid profile and intima media thickness (IMT) in rats fed on high-fat diet. Twenty young, adult male Sprague-Dawley (SD) rats were housed for 12 weeks. After one week of acclimatization, they were randomly divided into four groups of 5 animals each and treated for 12 weeks as follow: Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15mg/kg) dissolved in distilled water, group HFD was given only high fat diet and group HFDEL was given high fat diet and EL extracts (15mg/kg). Rats which were treated with EL (NDEL and HFDEL) showed a significant increase (p < 0.05) in the testosterone levels. There was a significant decrease (p < 0.05) in triglyceride (TG) in HFDEL group compered to HFD group. The histological sections of aortas revealed a significant decrease (p < 0.05) in IMT in HFDEL as compared with HFD group. No histological changes were observed in NDEL group compared with ND group and there was no significant difference in IMT values between NDEL and ND. These findings suggest that EL is a promising protective agent against atherosclerosis induced by high-fat diet.
dc.description.natureFinalen_US
dc.identifier.epage90
dc.identifier.issn18234631
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85020067567
dc.identifier.spage83
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85020067567&partnerID=40&md5=71fc35f5df6c849d18c8cd73b4517ce3
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8840
dc.identifier.volume16
dc.languageEnglish
dc.language.isoen_US
dc.publisherInternational Islamic University Malaysiaen_US
dc.relation.ispartofInternational Medical Journal Malaysia
dc.sourceScopus
dc.subjectAtherosclerosisen_US
dc.subjectCardiovascular diseasesen_US
dc.subjectEurycoma longifolia (Tongkat Ali),en_US
dc.subjectHyperlipidemiaen_US
dc.subjectIntima media thicknessen_US
dc.subjectTestosteroneen_US
dc.titleAnti-atherosclerotic effects of Eurycoma longifolia (tongkat ali) in rats fed on high-fat diet
dc.typeArticleen_US
dspace.entity.typePublication

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