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Efficacy and safety of latanoprost/timolol fixed combination dosed twice daily compared to once daily in patients with primary open angle glaucoma

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dc.contributor.authorAnis Baidura Azalen_US
dc.contributor.authorSiti Husna Husseinen_US
dc.contributor.authorSeng Fai Tangen_US
dc.contributor.authorOthmaliza Othmanen_US
dc.contributor.authorNorshamsiah Md Dinen_US
dc.date.accessioned2024-05-29T02:28:52Z
dc.date.available2024-05-29T02:28:52Z
dc.date.issued2023
dc.date.submitted2024-2-6
dc.descriptionInternational Journal of Ophthalmology Volume 16 No. 8 Page (1243-1249)en_US
dc.description.abstractAIM: To evaluate whether latanoprost/timolol fixed combination (LTFC) dosed twice daily may provide further intraocular pressure (IOP) reduction and evaluate the safety profile at this dose.● METHODS: This is an open-labeled, randomized, prospective crossover study on fourty primary open angle glaucoma patients. Two weeks of washout period were followed by randomization to either once daily (OD, group A) or twice daily dosing (BD, group B) of LTFC for 4wk. After another 2-week washout period, the patients’ treatment dose was crossed-over for another 4wk. IOP reduction alongside ocular and systemic side effects were evaluated. ● RESULTS: Mean baseline IOP was 18.57±2.93 and 17.8±3.01 mm Hg before OD and BD dose respectively, (P=0.27). Mean IOP after BD dose was statistically lower (12.49±1.59 mm Hg) compared to OD (13.48±1.81 mm Hg, P=0.017). Although IOP reduction after BD dose was more (5.32±3.24 mm Hg, 29.89%) than after OD dosing (5.04 mm Hg, 27.14%), it did not reach statistical significance (P=0.68). Patients switched from OD to BD (group A) showed mean IOP reduction by 0.69 mm Hg [95% confidence interval (CI): -0.09 to 1.48 mm Hg, P=0.078]; but patients switched from BD to OD (group B) had significantly higher mean IOP by 1.25 mm Hg (95%CI: -2.04 to -0.46 mm Hg, P=0.006). BD dose had more ocular side effects albeit mild. ● CONCLUSION: Mean IOP after LTFC dosed twice daily is statistically lower, with additional mild side effects.en_US
dc.identifier.citationAzal AB, Hussein SH, Tang SF, Othman O, Din NM. Efficacy and safety of latanoprost/timolol fixed combination dosed twice daily compared to once daily in patients with primary open angle glaucoma. Int J Ophthalmol 2023;16(8):1243-1249en_US
dc.identifier.doi10.18240/ijo.2023.08.09
dc.identifier.epage1249
dc.identifier.issn2222-3959
dc.identifier.issue8 (August)
dc.identifier.spage1243
dc.identifier.urihttp://ies.ijo.cn/gjyken/article/pdf/20230809
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10785
dc.identifier.volume16
dc.language.isoen_USen_US
dc.publisherInternational Journal of Ophthalmology (c/o Editorial Office)en_US
dc.relation.ispartofInternational Journal of Ophthalmologyen_US
dc.subjectefficacy; fixed combination; latanoprost; timolol; primary open angle glaucoma; safetyen_US
dc.titleEfficacy and safety of latanoprost/timolol fixed combination dosed twice daily compared to once daily in patients with primary open angle glaucomaen_US
dc.typeArticleen_US
dspace.entity.typePublication
oaire.citation.endPage1249
oaire.citation.issue8
oaire.citation.startPage1243
oaire.citation.volume16

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