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Community-acquired Methicillin-resistant Staphylococcus Aureus In A Malaysian Tertiary Centre

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dc.contributor.authorZetti Zainol Rashiden_US
dc.contributor.authorNorazlah Baharien_US
dc.contributor.authorAmizah Othmanen_US
dc.contributor.authorRoslinda Jaafaren_US
dc.contributor.authorNurul Azmawati Binti Mohamed @ Abd Azizen_US
dc.contributor.authorIdimaz Jabbarien_US
dc.contributor.authorAnita Sulongen_US
dc.contributor.authorRohaidah Hashimen_US
dc.contributor.authorNorazah Ahmaden_US
dc.date.accessioned2024-05-28T04:21:47Z
dc.date.available2024-05-28T04:21:47Z
dc.date.issued2013
dc.description.abstractCommunity-acquired methicillin-resistant Staphylococcus aureus (CAMRSA) is a pathogen recognized to be distinct in both phenotype and genotype from hospital-acquired MRSA. We have identified CA-MRSA cases in Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia, including their antibiotic susceptibility patterns and genotypic characteristics. Cases were identified during January to December 2009 from routine clinical specimens, where culture and antibiotic susceptibility results yielded pauci-resistant MRSA isolates suspected as being CA-MRSA. The patients clinical data were collected and their specimens were sent for molecular confirmation and analysis. Five cases of CAMRSA were identified, which had a multi-sensitive pattern on antibiotic susceptibility tests and were resistant to only penicillin and oxacillin. All cases were skin and soft-tissue infections, including diabetic foot with gangrene, infected scalp hematoma, philtrum abscess in a healthcare worker, thrombophlebitis complicated with abscess and infected bedsore. All five cases were confirmed MRSA by detection of mecA. SCCmec typing (ccr and mec complex) revealed SCCmec type IV for all cases except the infected bedsore case. Panton-Valentine leukocidin gene was positive in all isolates. As clinical features among methicillin-sensitive Staphylococcus aureus, CA-MRSA and nosocomial CA-MRSA are indistinct, early recognition is necessary in order to initiate appropriate antibiotics and infection control measures. Continual surveillance of pauci-resistant MRSA and molecular analysis are necessary in order to identify emerging strains as well as their epidemiology and transmission, both in the community and in healthcare setting.en_US
dc.identifier.citationZainol Rashid, Z., Bahari, N., Othman, A., Jaafar, R., Mohamed, N. A., Jabbari, I., Sulong, A., Hashim, R., & Ahmad, N. (2011). Community-acquired methicillin-resistant Staphylococcus auereus in a Malaysian tertiary centre in year 2009. BMC Proceedings, 5(Suppl 6), P18. https://doi.org/10.1186/1753-6561-5-S6-P18en_US
dc.identifier.doi10.1186/1753-6561-5-S6-P18
dc.identifier.epage108
dc.identifier.issn0125-1562
dc.identifier.issue1
dc.identifier.other900-2
dc.identifier.spage104
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239599/
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/5363
dc.identifier.volume44
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofThe Southeast Asian Journal Of Tropical Medicine And Public Healthen_US
dc.subjectStaphylococcus aureus,en_US
dc.subjectcommunity-acquired methicillin-resistance,en_US
dc.subjectskin and soft tissue infections,en_US
dc.subjectMalaysiaen_US
dc.titleCommunity-acquired Methicillin-resistant Staphylococcus Aureus In A Malaysian Tertiary Centreen_US
dc.typeArticleen_US
dspace.entity.typePublication

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