Publication:
Salivary Iga Depression In Drug-influenced Gingival Enlargement Among Hypertensive Patients

Simple item page
dc.contributor.authorMuhammad Annurdin Sabarudinen_US
dc.contributor.authorHaslina Taiben_US
dc.contributor.authorWan Majdiah Wan Mohamaden_US
dc.contributor.authorSiti Lailatul Akmar Zainuddinen_US
dc.contributor.authorWan Syamimee Wan Ghazalien_US
dc.date.accessioned2024-05-28T04:25:04Z
dc.date.available2024-05-28T04:25:04Z
dc.date.issued2022
dc.date.submitted2023-1-26
dc.descriptionVol. 29, No. 1 (page: 30-35)en_US
dc.description.abstractDrug-influenced gingival enlargement (DIGE) among hypertensive patients is commonly associated with antihypertensive drugs such as calcium channel blockers (CCBs). Immune response alteration is one of the proposed mechanisms for DIGE. Immunoglobulin A (IgA) in saliva which involves in defense mechanism was shown to be affected in patients with DIGE. Objective: This study aimed to determine the association of salivary IgA level with DIGE. Methods: This cross-sectional study comprised 47 hypertensive patients who had consumed antihypertensive drugs for at least 3 months. Twenty-one (44.7%) males and 26 (55.3%) females had participated in this study. Data was analyzed using SPSS version 26.0. The p-value of less than 0.05 at a 95% confidence interval is considered statistically significant. Results: Eighty-three percent and 17.0% of hypertensive patients were on CCBs and non- CCBs respectively. Amlodipine was found to be the most common (55.3%) antihypertensive drug consumed. Twenty- one (44.7%) patients presented with DIGE. The salivary IgA level was significantly decreased (p=0.03) among hypertensive patients with DIGE [Median 4.9 ng/mL (IQR 5.268)] compared to those without DIGE [median 15.03 ng/mL (IQR 32.246)]. Conclusion: This data indicates the level of salivary IgA was significantly affected in patients with DIGE which may compromise the defense mechanism of saliva.en_US
dc.identifier.citationSabarudin, M., Taib, H., Wan Mohamad, W., Zainuddin, S., Wan Ghazali, W., & Misran, A. Salivary IgA Depression in Drug-Influenced Gingival Enlargement among Hypertensive Patients. J Dent Indones. 2022;29(1): 30-35en_US
dc.identifier.doi10.14693/jdi.v29i1.1295
dc.identifier.epage35
dc.identifier.issn2355-4800
dc.identifier.issue1
dc.identifier.spage30
dc.identifier.urihttps://scholarhub.ui.ac.id/jdi/vol29/iss1/5/
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/5577
dc.identifier.volume29
dc.language.isoen_USen_US
dc.publisherFaculty of Dentistry Universitas Indonesiaen_US
dc.relation.ispartofJournal of Dentistry Indonesiaen_US
dc.subjectdrug-influenced, gingival enlargement, calcium channel blocker, salivary IgA, anti-hypertensive drugsen_US
dc.titleSalivary Iga Depression In Drug-influenced Gingival Enlargement Among Hypertensive Patientsen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Salivary IgA Depression in Drug-Influenced Gingival Enlargement among Hypertensive Patients.pdf
Size:
366.41 KB
Format:
Adobe Portable Document Format
Download

Collections

Other Publications