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Effect of Age on the Protein Profile of Healthy Malay Adults and its Association with Cognitive Function Competency

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dc.Chemicals/CASprotein, 67254-75-5
dc.ManufacturersThermo, Germany
dc.TradenamesQ Exactive HF Orbitra, Thermo, Germany
dc.citedby2
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM) Medical Centre
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversiti Teknologi Mara (UTM)
dc.contributor.authorBakar Z.H.A.en_US
dc.contributor.authorDamanhuri H.A.en_US
dc.contributor.authorMakpol S.en_US
dc.contributor.authorKamaruddin W.M.A.W.en_US
dc.contributor.authorSani N.F.A.en_US
dc.contributor.authorHamzah A.I.Z.A.en_US
dc.contributor.authorKhairun Nain Nor Aripinen_US
dc.contributor.authorRani M.D.M.en_US
dc.contributor.authorNoh N.A.en_US
dc.contributor.authorRazali R.en_US
dc.contributor.authorMazlan M.en_US
dc.contributor.authorHamid H.A.en_US
dc.contributor.authorMohamad M.en_US
dc.contributor.authorNgah W.Z.W.en_US
dc.date.accessioned2024-05-28T08:33:16Z
dc.date.available2024-05-28T08:33:16Z
dc.date.issued2019
dc.description.abstractBackground: Many studies on biochemical and psychological variables have aimed to elucidate the association between aging and cognitive function. Demographic differences and protein expression have been reported to play a role in determining the cognitive capability of a population. Objective: This study aimed to determine the effect of age on the protein profile of Malay individuals and its association with cognitive competency. Methods: A total of 160 individuals were recruited and grouped accordingly. Cognitive competency of each subject was assessed with several neuropsychological tests. Plasma samples were collected and analyzed with Q Exactive HF Orbitrap. Proteins were identified and quantitated with MaxQuant and further analyzed with Perseus to determine differentially expressed proteins. PANTHER, Reactome, and STRING were applied for bioinformatics output. Results: Our data showed that the Malay individuals are vulnerable to the deterioration of cognitive function with aging, and most of the proteins were differentially expressed in concordance. Several physiological components and pathways were shown to be involved, giving a hint of a promising interpretation on the induction of aging toward the state of the Malays' cognitive function. Nevertheless, some proteins have shown a considerable interaction with the generated protein network, which provides a direction of focus for further investigation. Conclusion: This study demonstrated notable changes in the expression of several proteins as age increased. These changes provide a promising platform for understanding the biochemical factors affecting cognitive function in the Malay population. The exhibited network of protein-protein interaction suggests the possibility of implementing regulatory intervention in ameliorating Malay cognitive function.
dc.description.natureFinal
dc.identifier.CODENJADIF
dc.identifier.doi10.3233/JAD-180511
dc.identifier.epageS62
dc.identifier.isbn1875-8908
dc.identifier.issn13872877
dc.identifier.issues1
dc.identifier.pmid30594926
dc.identifier.scopus2-s2.0-85071312282
dc.identifier.scopusWOS:000481670800007
dc.identifier.spageS43
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85071312282&doi=10.3233%2fJAD-180511&partnerID=40&md5=18838ca33d3c231c5821b6f758a8bea0
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9052
dc.identifier.volume70
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherIOS Pressen_US
dc.relation.ispartofJournal Of Alzheimers Disease
dc.sourceScopus
dc.sourcetitleJournal of Alzheimer's Disease
dc.subjectAging
dc.subjectcognitive function
dc.subjectprotein profiling
dc.subjectblood sampling
dc.subjectneuropsychological test
dc.subjectMalay population
dc.titleEffect of Age on the Protein Profile of Healthy Malay Adults and its Association with Cognitive Function Competencyen_US
dc.title.alternativeJ. Alzheimer's Dis.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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