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Preoperative Protein Profiling Among Postoperative Cognitive Dysfunction (POCD) Patients Following Open-Heart Surgery: A Systematic Review and Integrated Bioinformatic Analysis

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dc.contributor.authorMarjanu Hikmah Elias
dc.contributor.authorNazefah Abdul Hamid
dc.contributor.authorSofwatul Mokhtarah Maluin
dc.contributor.authorShamsir Aris
dc.contributor.authorSuhaini Kadiman
dc.contributor.authorKamilah Muhammad Hafidz
dc.contributor.authorNorsham Juliana
dc.date.accessioned2024-11-18T17:05:26Z
dc.date.available2024-11-18T17:05:26Z
dc.date.issued2024
dc.date.submitted2024-11-18
dc.descriptionInternational Journal of Molecular Sciences, Volume 25 issue 22
dc.description.abstractThe inability to accurately predict the occurrence of postoperative cognitive dysfunction (POCD) among open-heart surgery patients leads to concerning increases in POCD cases. Preoperative circulating biomarkers are important to identify as they are non-invasive and could provide an early prediction of POCD development, allowing for earlier and more strategized interventions. However, to date, no robust circulating biomarkers have proven effective for preoperative POCD prediction. This systematic review aims to synthesize current evidence on preoperative protein profiling among POCD patients following open-heart surgery. Thus, a thorough literature search employing PubMed, EBSCOhost, Scopus, and Science Direct was carried out. This combination of keywords was used as part of the search strategy: (“Postoperative cognitive decline” OR “Postoperative cognitive disorders” OR “Postoperative cognitive dysfunction” OR “Postoperative cognitive complications”) AND (“Thoracic Surgery” OR “Cardiac Surgery” OR “Heart Surgery”) AND (“Protein expression” OR proteomic OR “Protein profiling”). Eight hundred and twenty-nine studies were retrieved and only clinical studies reporting the circulating preoperative differentially expressed Proteins (DEPs) in the POCD patients were selected. Six studies were selected following the inclusion and exclusion criteria. Only one preoperative DEP and four immediate postoperative DEPs were extracted from the studies. All four proteins were selected for analysis using DAVID, STRING, and Cytoscape software. Due to the very low number of proteins, no clusters have been identified. This systematic review demonstrates the lack of POCD preoperative biomarkers for open-heart-surgery patients. Thus, it is suggested that more studies can be conducted to fill this gap.
dc.identifier.citationMarjanu Hikmah Elias , Nazefah Abdul Hamid , Sofwatul Mokhtarah Maluin , Shamsir Aris , Suhaini Kadiman , Kamilah Muhammad Hafidz and Norsham Juliana (2024). Preoperative Protein Profiling Among Postoperative Cognitive Dysfunction (POCD) Patients Following Open-Heart Surgery: A Systematic Review and Integrated Bioinformatic Analysis. International Journal of Molecular Sciences, 25(22), https://doi.org/10.3390/ijms252212238
dc.identifier.doi10.3390/ijms252212238
dc.identifier.epage13
dc.identifier.issn1422-0067
dc.identifier.issue12238
dc.identifier.other2160-32
dc.identifier.spage1
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/25104
dc.identifier.urihttps://www.mdpi.com/1422-0067/25/22/12238
dc.identifier.volume25
dc.language.isoen_US
dc.publisherMDPI
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.issn1422-0067
dc.relation.journalInternational Journal of Molecular Sciences
dc.subjectpostoperative cognitive complications (POCD)
dc.subjectcardiac surgery
dc.subjectbiomarkers
dc.subjectprotein expression profiling
dc.subjectcognitive assessment
dc.titlePreoperative Protein Profiling Among Postoperative Cognitive Dysfunction (POCD) Patients Following Open-Heart Surgery: A Systematic Review and Integrated Bioinformatic Analysis
dc.typetext::journal::journal article::research article
dspace.entity.typePublication
oaire.citation.issue22
oaire.citation.volume25
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliationUniversiti Sains Islam Malaysia

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