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Anti-atherosclerotic Effects of Eurycoma Longifolia (Tongkat Ali) in Rats Fed on High-fat Diet

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dc.contributor.authorAl-Joufi, Fen_US
dc.contributor.authorSaxena, AKen_US
dc.contributor.authorAl-Ani, IMen_US
dc.contributor.authorTalib, NAen_US
dc.contributor.authorMokhtar, RHen_US
dc.contributor.authorKu-Zaifah, Nen_US
dc.date.accessioned2024-05-29T03:00:21Z
dc.date.available2024-05-29T03:00:21Z
dc.date.issued2017
dc.description.abstractAtherosclerosis in cardiovascular disease (CVD) is a growing health problem, especially in developing countries. Hyperlipidemia is known as a dominant risk factor for the development of atherosclerosis. This study was designed to investigate the effects of Eurycoma Longifolia (EL) also known as Malaysian Ginseng/Tongkat Ali on the testosterone level, biochemical changes of lipid profile and intima media thickness (IMT) in rats fed on high-fat diet. Twenty young, adult male Sprague-Dawley (SD) rats were housed for 12 weeks. After one week of acclimatization, they were randomly divided into four groups of 5 animals each and treated for 12 weeks as follow: Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15mg/kg) dissolved in distilled water, group HFD was given only high fat diet and group HFDEL was given high fat diet and EL extracts (15mg/kg). Rats which were treated with EL (NDEL and HFDEL) showed a significant increase (p<0.05) in the testosterone levels. There was a significant decrease (p<0.05) in triglyceride (TG) in HFDEL group compered to HFD group. The histological sections of aortas revealed a significant decrease (p<0.05) in IMT in HFDEL as compared with HFD group. No histological changes were observed in NDEL group compared with ND group and there was no significant difference in IMT values between NDEL and ND. These findings suggest that EL is a promising protective agent against atherosclerosis induced by high-fat diet.en_US
dc.identifier.epage89
dc.identifier.issn1823-4631
dc.identifier.issue1
dc.identifier.scopusWOS:000404717800011
dc.identifier.spage83
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11778
dc.identifier.volume16
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherInt Islamic Univ Malaysia, Kulliyyah Medicineen_US
dc.relation.ispartofInternational Medical Journal Malaysiaen_US
dc.sourceWeb Of Science (ISI)
dc.subjectAtherosclerosisen_US
dc.subjectcardiovascular diseasesen_US
dc.subjectEurycoma longifolia (Tongkat Ali)en_US
dc.subjecthyperlipidemiaen_US
dc.subjectintima media thicknessen_US
dc.subjecttestosteroneen_US
dc.titleAnti-atherosclerotic Effects of Eurycoma Longifolia (Tongkat Ali) in Rats Fed on High-fat Dieten_US
dc.typeArticleen_US
dspace.entity.typePublication

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