Publication:
Impact of Rapid Vaccination on Sars-Cov-2 Genomic Diversity: An Intervention to Minimise the Public Burden of the Pandemic

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dc.contributor.authorAmirah Azzeri
dc.contributor.authorShuhaila Mat-Sharani
dc.contributor.authorDanish A/L Kumareahsan
dc.contributor.authorIsmatul Nurul Asyikin Ismail
dc.contributor.authorMuhamad Arif Mohamad Jamali
dc.contributor.authorLiyana Azmi
dc.date.accessioned2024-06-16T06:27:36Z
dc.date.available2024-06-16T06:27:36Z
dc.date.issued2023
dc.date.submitted2024-1-29
dc.descriptionMalaysian Journal of Public Health Medicine Vol. 23 No. 2 (page: 151-159)
dc.description.abstractGlobal sharing of SARS-CoV-2 sequences enabled comprehensive analyses of COVID-19 genomic diversity and demographics. Yet, regional genomic surveillance is often neglected, leading to the possible oversight of novel mutations by public health authorities. Our study used the Global Initiative on Sharing Avian Influenza Data (GISAID) database to analyse infection patterns in the state of Negeri Sembilan, and compare infection patterns to the state of Selangor, in Malaysia. We discuss the impact of rapid vaccination on resulting single nucleotide variants (SNVs) and identified novel sporadic mutations may affect viral fitness and pathogenicity. Four hundred and seventeen SARS-CoV-2 sequences extracted from Negeri Sembilan from July 2021 until June 2022. Infection patterns based on pangolin lineages from Negeri Sembilan was compared to infections of the same period from Selangor. SNVs from the spike protein were sorted by frequency, with the lowest frequency variant submitted for functional prediction using PredictSNP. Negeri Sembilan exhibited a comparable infection pattern to Selangor, but with fewer Omicron sequences which was postulated to occur due to the rapid vaccination strategies by Negeri Sembilan. Omicron outbreaks were associated with eased lockdowns and policy changes in December 2021. From our extracted data, seventy novel SNVs in the spike protein of SARS-CoV-2 were extracted from this study. In silico predictions indicated five of the SNVs (S221L, L226S, V826L, C1240F and C1243F) to may cause functional defects to the spike protein. Rapid sequencing and analysis will aid policymaking for public health controls by detecting potential outbreaks within transient variants.
dc.identifier.citationAmirah Azzeri, Shuhaila Mat-Sharani, Danish A/L Kumareahsan, Ismatul Nurul Asyikin Ismail, Muhamad Arif Mohamad Jamali, & Liyana Azmi. (2023). Impact of Rapid Vaccination on Sars-Cov-2 Genomic Diversity: An Intervention to Minimise the Public Burden of the Pandemic. Malaysian Journal of Public Health Medicine, 23(2), 151–159. https://doi.org/10.37268/mjphm/vol.23/no.2/art.2305
dc.identifier.doi10.37268/mjphm/vol.23/no.2/art.2305
dc.identifier.epage159
dc.identifier.issn1675-0306
dc.identifier.issue2
dc.identifier.spage151
dc.identifier.urihttps://mjphm.org/index.php/mjphm/article/view/2305
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/19295
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85172272719&origin=resultslist&sort=plf-f&src=s&sid=ac9c090717895ca95b0841e5e9d65ffd&sot=b&sdt=b&s=TITLE-ABS-KEY%28Impact+of+Rapid+Vaccination+on+Sars-Cov-2+Genomic+Diversity%29&sl=74&sessionSearchId=ac9c090717895ca95b0841e5e9d65ffd&relpos=0
dc.identifier.volume23
dc.language.isoen_US
dc.publisherMalaysian Journal of Public Health Medicine
dc.relation.ispartofMalaysian Journal of Public Health Medicine
dc.relation.issn2590-3829
dc.relation.journalMalaysian Journal of Public Health Medicine
dc.subjectSARS-CoV-2
dc.subjectMalaysia variant
dc.subjectgenetic diversity
dc.subjectspike protein
dc.subjectpangolin replacement
dc.titleImpact of Rapid Vaccination on Sars-Cov-2 Genomic Diversity: An Intervention to Minimise the Public Burden of the Pandemic
dc.typetext::journal::journal article::research article
dspace.entity.typePublication
oaire.citation.endPage159
oaire.citation.issue2
oaire.citation.startPage151
oaire.citation.volume23
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliationUniversiti Sains Islam Malaysia

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