Publication:
The effects of Labisia pumila extracts on bone microarchitecture of ovariectomized-induced osteoporosis rats: A micro-CT analysis

dc.Chemicals/CASPlant Extracts
dc.citedby6
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM) Medical Centre
dc.contributor.affiliationsUniversiti Sains Malaysia (USM)
dc.contributor.authorEffendy N.M.en_US
dc.contributor.authorKhamis M.F.en_US
dc.contributor.authorShuid A.N.en_US
dc.date.accessioned2024-05-28T08:24:54Z
dc.date.available2024-05-28T08:24:54Z
dc.date.issued2017
dc.description.abstractBACKGOUND: Labisia pumila (LP) is a popular herb used by women over the past few decades. This herb has shown potentials as an alternative agent for treatment and prevention of postmenopausal osteoporosis. It was observed in previous studies that supplementation to ovariectomized rats were associated with increased bone antioxidative enzymes and reduced lipid peroxidation activity. It had also improved bone formation markers in ovariectomized rats. This study aimed to evaluate the effects of giving different forms of LP extracts on the trabecular bone microarchitecture of ovariectomised rats. METHODS: Forty-eight female Sprague-Dawley rats were randomly divided into sham-operated (Sham), ovariectomized control (OVX), ovariectomized and given estrogen at 64.5 ?g/kg (ERT), ovariectomized and given LP aqueous extract (LPaq), LP methanol extract (LPmet) and LP ethanol extract (LPet) at 100mg/kg, respectively. Treatments were given daily via oral gavages for nine weeks. Following sacrifice, femora were dissected out for bone microarchitectural analysis using an in vitro micro-CT, which provided three dimensional informations on bone microarchitecture. RESULTS: LPaq was the most effective extract found to improve the bone microarchitectural paramaters which comprised ofBone volume fraction (BV/TV), Trabecular separation (Tb.Sp), Trabecular number (Tb.N), Connective density (Conn.dens), Structure model index (SMI) and Degree of anisotropy (DA). CONCLUSION: LPaq was effective in protecting the bone of postmenopausal osteoporosis rat model against microarchitectural deterioration. � 2017 - IOS Press and the authors.en_US
dc.description.natureFinalen_US
dc.identifier.CODENJXSTE
dc.identifier.doi10.3233/XST-16115
dc.identifier.epage112
dc.identifier.issn8953996
dc.identifier.issue1
dc.identifier.pmid27768005
dc.identifier.scopus2-s2.0-85011589644
dc.identifier.spage101
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85011589644&doi=10.3233%2fXST-16115&partnerID=40&md5=0a2a1d671ddf25dbecd7c829c8efd821
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8580
dc.identifier.volume25
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherIOS Pressen_US
dc.relation.ispartofJournal of X-Ray Science and Technology
dc.sourceScopus
dc.subjectbone microarchitectureen_US
dc.subjectimagingen_US
dc.subjectLabisia pumilaen_US
dc.subjectmicro-CTen_US
dc.subjectosteoporosisen_US
dc.titleThe effects of Labisia pumila extracts on bone microarchitecture of ovariectomized-induced osteoporosis rats: A micro-CT analysisen_US
dc.title.alternativeJ X Ray Sci Technolen_US
dc.typeArticleen_US
dspace.entity.typePublication

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